Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529124868> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1529124868 endingPage "197.1" @default.
- W1529124868 startingPage "197.1" @default.
- W1529124868 abstract "Abstract Oropharyngeal candidiasis (OPC) is an opportunistic mucosal infection caused by the commensal fungus Candida albicans. To date, there is a paucity of research on oral mucosal immunity in general and to fungi in particular. Humans with rare mutations have revealed a vital protective role of IL-17 signaling to OPC. It has long been assumed that conventional “iTh17” cells produce IL-17. However, many innate populations also produce IL-17, but their role in oral immunity is unknown. Since rodents are naïve to C. albicans, we evaluated OPC in a murine model. T cell receptor rearrangement is required for immunity, since Rag1-/-, SCID and IL-7Rα-/- mice are susceptible to OPC. However, iTh17, NK and NKT cells were dispensable. We identified a CD3+CD4+CD44hiTCRβ+ tissue-resident population in tongue that produces IL-17 rapidly upon Candida exposure. These were phenotypically identical to ‘natural Th17’ cells, a recently described, thymically derived innate lymphocyte population whose function is highly enigmatic. Development of nTh17 and iTh17 cells involves differential AKT/mTOR pathways, with nTh17 cells requiring mTORC2, and iTH17 cells requiring mTORC1. Consistently, mice deficient in the mTORC2 subunit Rictor were highly susceptible to OPC, whereas mice treated with rapamycin, which selectively targets mTORC1, were similar to WT mice. Therefore, innate immunity to Candida requires nTh17 cells, whose presence in the oral mucosa ideally positions them to control oral pathogens." @default.
- W1529124868 created "2016-06-24" @default.
- W1529124868 creator A5005500510 @default.
- W1529124868 creator A5015859389 @default.
- W1529124868 creator A5020370363 @default.
- W1529124868 creator A5026972754 @default.
- W1529124868 creator A5036946722 @default.
- W1529124868 creator A5046441344 @default.
- W1529124868 creator A5049895849 @default.
- W1529124868 creator A5051952079 @default.
- W1529124868 creator A5066660712 @default.
- W1529124868 creator A5066775052 @default.
- W1529124868 creator A5069651723 @default.
- W1529124868 creator A5069742204 @default.
- W1529124868 creator A5080366618 @default.
- W1529124868 creator A5084213389 @default.
- W1529124868 creator A5086035743 @default.
- W1529124868 creator A5086447914 @default.
- W1529124868 date "2014-05-01" @default.
- W1529124868 modified "2023-10-12" @default.
- W1529124868 title "“Natural” Th17 cells control <i>Candida albicans</i> infections in the oral mucosa (MUC7P.749)" @default.
- W1529124868 doi "https://doi.org/10.4049/jimmunol.192.supp.197.1" @default.
- W1529124868 hasPublicationYear "2014" @default.
- W1529124868 type Work @default.
- W1529124868 sameAs 1529124868 @default.
- W1529124868 citedByCount "0" @default.
- W1529124868 crossrefType "journal-article" @default.
- W1529124868 hasAuthorship W1529124868A5005500510 @default.
- W1529124868 hasAuthorship W1529124868A5015859389 @default.
- W1529124868 hasAuthorship W1529124868A5020370363 @default.
- W1529124868 hasAuthorship W1529124868A5026972754 @default.
- W1529124868 hasAuthorship W1529124868A5036946722 @default.
- W1529124868 hasAuthorship W1529124868A5046441344 @default.
- W1529124868 hasAuthorship W1529124868A5049895849 @default.
- W1529124868 hasAuthorship W1529124868A5051952079 @default.
- W1529124868 hasAuthorship W1529124868A5066660712 @default.
- W1529124868 hasAuthorship W1529124868A5066775052 @default.
- W1529124868 hasAuthorship W1529124868A5069651723 @default.
- W1529124868 hasAuthorship W1529124868A5069742204 @default.
- W1529124868 hasAuthorship W1529124868A5080366618 @default.
- W1529124868 hasAuthorship W1529124868A5084213389 @default.
- W1529124868 hasAuthorship W1529124868A5086035743 @default.
- W1529124868 hasAuthorship W1529124868A5086447914 @default.
- W1529124868 hasConcept C136449434 @default.
- W1529124868 hasConcept C203014093 @default.
- W1529124868 hasConcept C2779341262 @default.
- W1529124868 hasConcept C2780917455 @default.
- W1529124868 hasConcept C2908647359 @default.
- W1529124868 hasConcept C62478195 @default.
- W1529124868 hasConcept C71924100 @default.
- W1529124868 hasConcept C86554907 @default.
- W1529124868 hasConcept C86803240 @default.
- W1529124868 hasConcept C8891405 @default.
- W1529124868 hasConcept C89423630 @default.
- W1529124868 hasConcept C95444343 @default.
- W1529124868 hasConcept C98490376 @default.
- W1529124868 hasConcept C99454951 @default.
- W1529124868 hasConceptScore W1529124868C136449434 @default.
- W1529124868 hasConceptScore W1529124868C203014093 @default.
- W1529124868 hasConceptScore W1529124868C2779341262 @default.
- W1529124868 hasConceptScore W1529124868C2780917455 @default.
- W1529124868 hasConceptScore W1529124868C2908647359 @default.
- W1529124868 hasConceptScore W1529124868C62478195 @default.
- W1529124868 hasConceptScore W1529124868C71924100 @default.
- W1529124868 hasConceptScore W1529124868C86554907 @default.
- W1529124868 hasConceptScore W1529124868C86803240 @default.
- W1529124868 hasConceptScore W1529124868C8891405 @default.
- W1529124868 hasConceptScore W1529124868C89423630 @default.
- W1529124868 hasConceptScore W1529124868C95444343 @default.
- W1529124868 hasConceptScore W1529124868C98490376 @default.
- W1529124868 hasConceptScore W1529124868C99454951 @default.
- W1529124868 hasIssue "1_Supplement" @default.
- W1529124868 hasLocation W15291248681 @default.
- W1529124868 hasOpenAccess W1529124868 @default.
- W1529124868 hasPrimaryLocation W15291248681 @default.
- W1529124868 hasRelatedWork W2006838528 @default.
- W1529124868 hasRelatedWork W2012994110 @default.
- W1529124868 hasRelatedWork W2103515427 @default.
- W1529124868 hasRelatedWork W2126012192 @default.
- W1529124868 hasRelatedWork W2152087265 @default.
- W1529124868 hasRelatedWork W241118077 @default.
- W1529124868 hasRelatedWork W2986423947 @default.
- W1529124868 hasRelatedWork W3030989749 @default.
- W1529124868 hasRelatedWork W4306408058 @default.
- W1529124868 hasRelatedWork W4313383734 @default.
- W1529124868 hasVolume "192" @default.
- W1529124868 isParatext "false" @default.
- W1529124868 isRetracted "false" @default.
- W1529124868 magId "1529124868" @default.
- W1529124868 workType "article" @default.