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- W1529127714 abstract "Abstract The activation of the CD4+ T cell immune response to pathogens is determined by the interaction between the T cell receptor and its cognate pathogen-derived peptide presented by MHC-II molecules on antigen-presenting cells (APCs). In vitro, whether a given CD4+ T cell will undergo activation is determined by the potency and density of the activating ligand. We created an in vivo murine model to identify how ligand potency and ligand density impact the overall cross-reactivity of an anti-viral CD4+ T cell response. We observed graded CD4+ T cell responses after immunization by strong, medium, or weak affinity ligands, with phenotypic differences evident within 24 hours and with long-term effects on the repertoire and clonal expansion. In addition, vaccinia viruses that expressed a high density ligand on the surface of APCs generated an expanded profile of CD4+ T cell specificities compared to that generated in response to lower density antigen. This occurred because medium affinity CD4+ T cells were able to be activated and expanded in the presence of high but not low antigen density." @default.
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- W1529127714 date "2012-05-01" @default.
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- W1529127714 title "<b>Antigen density determines the pattern of pMHC cross-reactivity of CD4+ T cell responses during viral infection</b>(69.8)" @default.
- W1529127714 doi "https://doi.org/10.4049/jimmunol.188.supp.69.8" @default.
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