FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529133069> ?p ?o ?g. }

• W1529133069 endingPage "948" @default.
• W1529133069 startingPage "940" @default.
• W1529133069 abstract "Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) are members of the DEAD box helicases, and recognize viral RNA in the cytoplasm, leading to IFN-β induction through the adaptor IFN-β promoter stimulator-1 (IPS-1) (also known as Cardif, mitochondrial antiviral signaling protein or virus-induced signaling adaptor). Since uninfected cells usually harbor a trace of RIG-I, other RNA-binding proteins may participate in assembling viral RNA into the IPS-1 pathway during the initial response to infection. We searched for proteins coupling with human IPS-1 by yeast two-hybrid and identified another DEAD (Asp-Glu-Ala-Asp) box helicase, DDX3 (DEAD/H BOX 3). DDX3 can bind viral RNA to join it in the IPS-1 complex. Unlike RIG-I, DDX3 was constitutively expressed in cells, and some fraction of DDX3 is colocalized with IPS-1 around mitochondria. The 622-662 a.a DDX3 C-terminal region (DDX3-C) directly bound to the IPS-1 CARD-like domain, and the whole DDX3 protein also associated with RLR. By reporter assay, DDX3 helped IPS-1 up-regulate IFN-β promoter activation and knockdown of DDX3 by siRNA resulted in reduced IFN-β induction. This activity was conserved on the DDX3-C fragment. DDX3 only marginally enhanced IFN-β promoter activation induced by transfected TANK-binding kinase 1 (TBK1) or I-kappa-B kinase-ε (IKKε). Forced expression of DDX3 augmented virus-mediated IFN-β induction and host cell protection against virus infection. Hence, DDX3 is an antiviral IPS-1 enhancer." @default.
• W1529133069 created "2016-06-24" @default.
• W1529133069 creator A5033434458 @default.
• W1529133069 creator A5043184323 @default.
• W1529133069 creator A5071402791 @default.
• W1529133069 creator A5089860635 @default.
• W1529133069 date "2010-02-01" @default.
• W1529133069 modified "2023-10-10" @default.
• W1529133069 title "DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-β-inducing potential" @default.
• W1529133069 cites W1667782349 @default.
• W1529133069 cites W1955412606 @default.
• W1529133069 cites W1969776705 @default.
• W1529133069 cites W1990521726 @default.
• W1529133069 cites W1993457378 @default.
• W1529133069 cites W1993849863 @default.
• W1529133069 cites W2013601771 @default.
• W1529133069 cites W2017515700 @default.
• W1529133069 cites W2018828712 @default.
• W1529133069 cites W2028575270 @default.
• W1529133069 cites W2031434197 @default.
• W1529133069 cites W2065554630 @default.
• W1529133069 cites W2066691052 @default.
• W1529133069 cites W2067706259 @default.
• W1529133069 cites W2068551986 @default.
• W1529133069 cites W2076031827 @default.
• W1529133069 cites W2078188527 @default.
• W1529133069 cites W2085795760 @default.
• W1529133069 cites W2090457486 @default.
• W1529133069 cites W2093579074 @default.
• W1529133069 cites W2103500013 @default.
• W1529133069 cites W2107513655 @default.
• W1529133069 cites W2129976921 @default.
• W1529133069 cites W2137303998 @default.
• W1529133069 cites W2140700343 @default.
• W1529133069 cites W2141137217 @default.
• W1529133069 cites W2141425521 @default.
• W1529133069 cites W2154672212 @default.
• W1529133069 doi "https://doi.org/10.1002/eji.200940203" @default.
• W1529133069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20127681" @default.
• W1529133069 hasPublicationYear "2010" @default.
• W1529133069 type Work @default.
• W1529133069 sameAs 1529133069 @default.
• W1529133069 citedByCount "177" @default.
• W1529133069 countsByYear W15291330692012 @default.
• W1529133069 countsByYear W15291330692013 @default.
• W1529133069 countsByYear W15291330692014 @default.
• W1529133069 countsByYear W15291330692015 @default.
• W1529133069 countsByYear W15291330692016 @default.
• W1529133069 countsByYear W15291330692017 @default.
• W1529133069 countsByYear W15291330692018 @default.
• W1529133069 countsByYear W15291330692019 @default.
• W1529133069 countsByYear W15291330692020 @default.
• W1529133069 countsByYear W15291330692021 @default.
• W1529133069 countsByYear W15291330692022 @default.
• W1529133069 countsByYear W15291330692023 @default.
• W1529133069 crossrefType "journal-article" @default.
• W1529133069 hasAuthorship W1529133069A5033434458 @default.
• W1529133069 hasAuthorship W1529133069A5043184323 @default.
• W1529133069 hasAuthorship W1529133069A5071402791 @default.
• W1529133069 hasAuthorship W1529133069A5089860635 @default.
• W1529133069 hasBestOaLocation W15291330691 @default.
• W1529133069 hasConcept C104317684 @default.
• W1529133069 hasConcept C153911025 @default.
• W1529133069 hasConcept C161223559 @default.
• W1529133069 hasConcept C173396325 @default.
• W1529133069 hasConcept C183786373 @default.
• W1529133069 hasConcept C2776954689 @default.
• W1529133069 hasConcept C2779568538 @default.
• W1529133069 hasConcept C55493867 @default.
• W1529133069 hasConcept C62478195 @default.
• W1529133069 hasConcept C67705224 @default.
• W1529133069 hasConcept C68592252 @default.
• W1529133069 hasConcept C86803240 @default.
• W1529133069 hasConcept C95444343 @default.
• W1529133069 hasConceptScore W1529133069C104317684 @default.
• W1529133069 hasConceptScore W1529133069C153911025 @default.
• W1529133069 hasConceptScore W1529133069C161223559 @default.
• W1529133069 hasConceptScore W1529133069C173396325 @default.
• W1529133069 hasConceptScore W1529133069C183786373 @default.
• W1529133069 hasConceptScore W1529133069C2776954689 @default.
• W1529133069 hasConceptScore W1529133069C2779568538 @default.
• W1529133069 hasConceptScore W1529133069C55493867 @default.
• W1529133069 hasConceptScore W1529133069C62478195 @default.
• W1529133069 hasConceptScore W1529133069C67705224 @default.
• W1529133069 hasConceptScore W1529133069C68592252 @default.
• W1529133069 hasConceptScore W1529133069C86803240 @default.
• W1529133069 hasConceptScore W1529133069C95444343 @default.
• W1529133069 hasIssue "4" @default.
• W1529133069 hasLocation W15291330691 @default.
• W1529133069 hasLocation W15291330692 @default.
• W1529133069 hasOpenAccess W1529133069 @default.
• W1529133069 hasPrimaryLocation W15291330691 @default.
• W1529133069 hasRelatedWork W1529133069 @default.
• W1529133069 hasRelatedWork W1732942398 @default.
• W1529133069 hasRelatedWork W1915598723 @default.
• W1529133069 hasRelatedWork W2023651356 @default.
• W1529133069 hasRelatedWork W2045055049 @default.
• W1529133069 hasRelatedWork W2058819725 @default.

• next