Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529182844> ?p ?o ?g. }
- W1529182844 endingPage "155" @default.
- W1529182844 startingPage "147" @default.
- W1529182844 abstract "beta-Lactam resistance in enteric bacteria is frequently caused by mutations in ampD encoding a cytosolic N-acetylmuramyl- l-alanine amidase. Such mutants are blocked in murein (peptidoglycan) recycling and accumulate cytoplasmic muropeptides that interact with the transcriptional activator ampR, which de-represses beta-lactamase expression. Salmonella enterica serovar Typhimurium, an extensively studied enteric pathogen, was used to show that mutations in ampD decreased the ability of S. typhimurium to enter a macrophage derived cell line and made the bacteria more potent as inducers of inducible nitric oxide synthase (iNOS), as compared with the wild-type. ampG mutants, defective in the transport of recycled muropeptides across the cytoplasmic membrane, behaved essentially as the wild-type in invasion assays and in activation of iNOS. As ampD mutants also have reduced in vivo fitness in a murine model, we suggest that the cytoplasmic accumulation of muropeptides affects the virulence of the ampD mutants." @default.
- W1529182844 created "2016-06-24" @default.
- W1529182844 creator A5016181461 @default.
- W1529182844 creator A5039373219 @default.
- W1529182844 creator A5047292857 @default.
- W1529182844 creator A5048803658 @default.
- W1529182844 creator A5089043381 @default.
- W1529182844 date "2004-10-13" @default.
- W1529182844 modified "2023-10-05" @default.
- W1529182844 title "Components of the peptidoglycan-recycling pathway modulate invasion and intracellular survival of Salmonella enterica serovar Typhimurium" @default.
- W1529182844 cites W1560114212 @default.
- W1529182844 cites W1624615502 @default.
- W1529182844 cites W1649027544 @default.
- W1529182844 cites W1862840600 @default.
- W1529182844 cites W1938034723 @default.
- W1529182844 cites W1966871526 @default.
- W1529182844 cites W1968770432 @default.
- W1529182844 cites W1970387516 @default.
- W1529182844 cites W1974016379 @default.
- W1529182844 cites W1979767547 @default.
- W1529182844 cites W1995321760 @default.
- W1529182844 cites W1997933100 @default.
- W1529182844 cites W1999236418 @default.
- W1529182844 cites W2003634035 @default.
- W1529182844 cites W2019655319 @default.
- W1529182844 cites W2032138966 @default.
- W1529182844 cites W2040024879 @default.
- W1529182844 cites W2040200245 @default.
- W1529182844 cites W2056538346 @default.
- W1529182844 cites W2066286375 @default.
- W1529182844 cites W2081485204 @default.
- W1529182844 cites W2085430726 @default.
- W1529182844 cites W2094806927 @default.
- W1529182844 cites W2103851237 @default.
- W1529182844 cites W2106868749 @default.
- W1529182844 cites W2108981715 @default.
- W1529182844 cites W2116137883 @default.
- W1529182844 cites W2120146872 @default.
- W1529182844 cites W2123680076 @default.
- W1529182844 cites W2125309974 @default.
- W1529182844 cites W2131797980 @default.
- W1529182844 cites W2138067578 @default.
- W1529182844 cites W2138270253 @default.
- W1529182844 cites W2139909177 @default.
- W1529182844 cites W2145500507 @default.
- W1529182844 cites W2145844007 @default.
- W1529182844 cites W2152419408 @default.
- W1529182844 cites W2154986946 @default.
- W1529182844 cites W31581040 @default.
- W1529182844 doi "https://doi.org/10.1111/j.1462-5822.2004.00443.x" @default.
- W1529182844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15617530" @default.
- W1529182844 hasPublicationYear "2004" @default.
- W1529182844 type Work @default.
- W1529182844 sameAs 1529182844 @default.
- W1529182844 citedByCount "38" @default.
- W1529182844 countsByYear W15291828442012 @default.
- W1529182844 countsByYear W15291828442013 @default.
- W1529182844 countsByYear W15291828442014 @default.
- W1529182844 countsByYear W15291828442016 @default.
- W1529182844 countsByYear W15291828442017 @default.
- W1529182844 countsByYear W15291828442018 @default.
- W1529182844 countsByYear W15291828442019 @default.
- W1529182844 countsByYear W15291828442022 @default.
- W1529182844 countsByYear W15291828442023 @default.
- W1529182844 crossrefType "journal-article" @default.
- W1529182844 hasAuthorship W1529182844A5016181461 @default.
- W1529182844 hasAuthorship W1529182844A5039373219 @default.
- W1529182844 hasAuthorship W1529182844A5047292857 @default.
- W1529182844 hasAuthorship W1529182844A5048803658 @default.
- W1529182844 hasAuthorship W1529182844A5089043381 @default.
- W1529182844 hasConcept C104317684 @default.
- W1529182844 hasConcept C143065580 @default.
- W1529182844 hasConcept C207583985 @default.
- W1529182844 hasConcept C2776634448 @default.
- W1529182844 hasConcept C2778910516 @default.
- W1529182844 hasConcept C2779607309 @default.
- W1529182844 hasConcept C2781065037 @default.
- W1529182844 hasConcept C523546767 @default.
- W1529182844 hasConcept C54355233 @default.
- W1529182844 hasConcept C547475151 @default.
- W1529182844 hasConcept C55493867 @default.
- W1529182844 hasConcept C60987743 @default.
- W1529182844 hasConcept C86803240 @default.
- W1529182844 hasConcept C89423630 @default.
- W1529182844 hasConceptScore W1529182844C104317684 @default.
- W1529182844 hasConceptScore W1529182844C143065580 @default.
- W1529182844 hasConceptScore W1529182844C207583985 @default.
- W1529182844 hasConceptScore W1529182844C2776634448 @default.
- W1529182844 hasConceptScore W1529182844C2778910516 @default.
- W1529182844 hasConceptScore W1529182844C2779607309 @default.
- W1529182844 hasConceptScore W1529182844C2781065037 @default.
- W1529182844 hasConceptScore W1529182844C523546767 @default.
- W1529182844 hasConceptScore W1529182844C54355233 @default.
- W1529182844 hasConceptScore W1529182844C547475151 @default.
- W1529182844 hasConceptScore W1529182844C55493867 @default.
- W1529182844 hasConceptScore W1529182844C60987743 @default.
- W1529182844 hasConceptScore W1529182844C86803240 @default.
- W1529182844 hasConceptScore W1529182844C89423630 @default.