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- W1529387617 abstract "A host of central neurotransmitter systems subserving γ-aminobutyric acid (GABA)ergic, glutamatergic, adrenergic, serotonergic, and cholinergic transmission are likely affected by anesthetics. Anesthetic drugs interfere with cholinergic processes associated with altered states of consciousness. For example, administration of opiates, halothane, isoflurane, and enflurane are associated with decreased acetylcholine (ACh) release from neurones in the laterodorsal and pedunculopontine tegmental (LDT/PPT) nuclei projecting to the medial pontine reticular formation. Conversely, drugs that directly affect cholinergic activity also influence minimum alveolar concentration (MAC). There is one possibility that general anesthetics interfere directly with cholinergic transmission to produce unconsciousness. A series of experiments presented focuses on a hypothesis that the loss of consciousness produced by anesthetic drugs involves depression, directly or indirectly, of central cholinergic transmission. It was investigated whether physostigmine, a centrally-acting anticholinesterase, reverses the loss of consciousness produced by continuous administration of anesthetic drugs. In addition, it was determined whether the reversal was blocked by scopolamine, a nonselective centrally-acting muscarinic antagonist." @default.
- W1529387617 created "2016-06-24" @default.
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- W1529387617 date "2004-01-01" @default.
- W1529387617 modified "2023-10-11" @default.
- W1529387617 title "Cholinergic mechanisms mediating anesthetic induced altered states of consciousness" @default.
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- W1529387617 doi "https://doi.org/10.1016/s0079-6123(03)45014-0" @default.
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