FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W152954902> ?p ?o ?g. }

• W152954902 endingPage "16" @default.
• W152954902 startingPage "103" @default.
• W152954902 abstract "A histomorphometric (planimetric) study was performed on trephine biopsies of the bone marrow taken at presentation from 65 patients (31 males and 34 females, with a median age of 48 years) with chronic myeloid leukemia (CML). Specimens from 20 patients (9 males and 11 females, with a median age of 53 years) without any hematologic disorders served as controls. Of the various histologic variables tested, only the counts of neutrophilic granulocytes per 1 sq mm, the ratio of granulocytopoiesis to megakaryopoiesis and the density of reticulin (argyrophilic) fibers revealed a significant correlation with the prognosis. The CML patients were separated into two groups with different survival patterns. Group I (34 patients with a median survival of 24 months) mostly contained cases with the so-called megakaryocytic subtype of CML, which is accompanied by variable degrees of fibrosis; group II (31 patients with a median survival of 36 months) mainly contained cases with the granulocytic subtype, which is not accompanied by myelofibrosis. Among the morphometric parameters, a positive correlation existed between the megakaryocyte count and the reticulin fiber density, which underlines the important role of that cell lineage in fibrillogenesis. There were multiple interrelationships between the histomorphometric variables and the laboratory data. Consequently, multivariate regression methods (using Cox's proportional hazards model) were applied to assess the relative predictive value of the patient characteristics for survival. The derived prognostic model divided the patients into two risk groups, with median survivals of 14 and 41 months, respectively. In order of their entry into the regression model, these variables were percentage of neutrophils in the differential blood count, amount of granulopoiesis, liver size, percentage of peripheral myeloblasts and density of reticulin fibers in the bone marrow. In comparing the two patient groups, based on bone marrow histomorphometric parameters, this model revealed that two of those factors (amount of granulopoiesis and density of reticulin fibers) had a significant correlation with the prognosis." @default.
• W152954902 created "2016-06-24" @default.
• W152954902 creator A5036871832 @default.
• W152954902 creator A5049288387 @default.
• W152954902 creator A5068754385 @default.
• W152954902 creator A5070364015 @default.
• W152954902 date "1990-04-01" @default.
• W152954902 modified "2023-09-23" @default.
• W152954902 title "A histomorphometric analysis of trephine biopsies of bone marrow from 65 patients with chronic myeloid leukemia. Classification of patients into subgroups with different survival patterns." @default.
• W152954902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2350386" @default.
• W152954902 hasPublicationYear "1990" @default.
• W152954902 type Work @default.
• W152954902 sameAs 152954902 @default.
• W152954902 citedByCount "6" @default.
• W152954902 crossrefType "journal-article" @default.
• W152954902 hasAuthorship W152954902A5036871832 @default.
• W152954902 hasAuthorship W152954902A5049288387 @default.
• W152954902 hasAuthorship W152954902A5068754385 @default.
• W152954902 hasAuthorship W152954902A5070364015 @default.
• W152954902 hasConcept C126322002 @default.
• W152954902 hasConcept C142724271 @default.
• W152954902 hasConcept C2776232749 @default.
• W152954902 hasConcept C2778729363 @default.
• W152954902 hasConcept C2779282312 @default.
• W152954902 hasConcept C2780007613 @default.
• W152954902 hasConcept C2780076729 @default.
• W152954902 hasConcept C50382708 @default.
• W152954902 hasConcept C71924100 @default.
• W152954902 hasConcept C90924648 @default.
• W152954902 hasConceptScore W152954902C126322002 @default.
• W152954902 hasConceptScore W152954902C142724271 @default.
• W152954902 hasConceptScore W152954902C2776232749 @default.
• W152954902 hasConceptScore W152954902C2778729363 @default.
• W152954902 hasConceptScore W152954902C2779282312 @default.
• W152954902 hasConceptScore W152954902C2780007613 @default.
• W152954902 hasConceptScore W152954902C2780076729 @default.
• W152954902 hasConceptScore W152954902C50382708 @default.
• W152954902 hasConceptScore W152954902C71924100 @default.
• W152954902 hasConceptScore W152954902C90924648 @default.
• W152954902 hasIssue "2" @default.
• W152954902 hasLocation W1529549021 @default.
• W152954902 hasOpenAccess W152954902 @default.
• W152954902 hasPrimaryLocation W1529549021 @default.
• W152954902 hasRelatedWork W1986759275 @default.
• W152954902 hasRelatedWork W2045006939 @default.
• W152954902 hasRelatedWork W2081736045 @default.
• W152954902 hasRelatedWork W2111192733 @default.
• W152954902 hasRelatedWork W2122605148 @default.
• W152954902 hasRelatedWork W2372799858 @default.
• W152954902 hasRelatedWork W2411080555 @default.
• W152954902 hasRelatedWork W2430403399 @default.
• W152954902 hasRelatedWork W2461999025 @default.
• W152954902 hasRelatedWork W77255247 @default.
• W152954902 hasVolume "12" @default.
• W152954902 isParatext "false" @default.
• W152954902 isRetracted "false" @default.
• W152954902 magId "152954902" @default.
• W152954902 workType "article" @default.