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- W1529561208 abstract "The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Orodispersible tablets of Ondansetron hydrochloride were prepared to achieve quick onset of action and for maximum bioavailability. The objective of the present research was to compare the effect of different superdisintegrants on the mouth dissolving property of Ondansetron hydrochloride tablets. Orodispersible tablets of Ondansetron hydrochloride were prepared using sodium carboxy methyl cellulose, alginic acid, crospovidone, croscarmellose sodium and sodium starch glycollate as superdisintegrants by direct compression technique. Prepared orodispersible tablets were evaluated for weight variation, hardness, friability, content uniformity, wetting time, in vitro dispersion time, in vitro disintegration time and dissolution studies. Disintegration time from all the prepared formulation was found to be in following order: F3<F5<F1<F4<F2. Disintegration time was found to be rapid in F3 formulation. The in vitro dissolution time was found to be 99.77 ± 0.32 in 10 minutes for the formulation F3. Sodium starch glycollate (SSG) showed faster disintegration of tablets among all other superdisintegrants. KEY WORDS: Ondansetron hydrochloride, orodispersible tablet, Sodium starch glycollate, direct compression, superdisintegrants" @default.
- W1529561208 created "2016-06-24" @default.
- W1529561208 creator A5010407596 @default.
- W1529561208 date "2013-03-10" @default.
- W1529561208 modified "2023-09-25" @default.
- W1529561208 title "FORMULATION AND OPTIMIZATION OF ONDANSETRON HYDROCHLORIDE ORODISPERSIBLE TABLETS" @default.
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