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• W1529569096 abstract "The antipsychotic drugs provide the main treatment for the serious brain disorder schizophrenia. They have enabled many people to lead normal lives but their use is associated with serious side effects. It had been the dogma for many years that the antipsychotic drugs were acting as antagonists at the D 2 -like dopamine receptors. A detailed examination of the inverse agonism of the antipsychotic drugs was performed using a CHO cell line expressing the native D 2 dopamine receptor at high levels (4–6 μmol/mg). Using these cells, it was possible to show that all of the antipsychotic drugs tested exhibited inverse agonism at the D 2 receptor based on their ability to potentiate forskolin stimulated cAMP production. This was seen for different chemical classes of drug and for drugs with different clinical profiles, for example, high or low side effects. The extent of inverse agonism was similar for each drug so that they all appeared to be full inverse agonists and there was a good correlation between inverse agonist potency and binding affinity." @default.
• W1529569096 created "2016-06-24" @default.
• W1529569096 creator A5007627492 @default.
• W1529569096 date "2002-01-01" @default.
• W1529569096 modified "2023-09-27" @default.
• W1529569096 title "Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D2 dopamine receptor" @default.
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• W1529569096 doi "https://doi.org/10.1016/s0165-7208(02)80018-6" @default.
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