Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529599013> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1529599013 endingPage "642" @default.
- W1529599013 startingPage "637" @default.
- W1529599013 abstract "The techniques of fluorescence enhancement and fluorescence polarization were used to study the binding of NADPH and structurally similar pyridine nucleotides to pigeon and rat liver fatty acid synthetases. NADPH, on binding to the enzyme, changes from a closed to an open conformation and the nicotinamide ring becomes associated with hydrophobic groups of the protein. The orientation of NADPH when bound to enzyme is such as to permit the transfer of radiant energy from tryptophan residues of the protein to the nicotinamide moiety of NADPH. The binding affinity of the enzyme for the coenzyme is considerably reduced by removal of the 2'-ribose phosphate (NADH), and by oxidation of the pyridine ring (NADP), but it is only slightly decreased by alteration of substituents on the adenine and pyridine rings (deamino-NADP and acetylpyridine-NADP). Enzyme-bound NADH is not aligned with the enzyme in the same manner as NADPH. The binding of NADPH to enzyme is competitively inhibited by pyridine nucleotide analogues, and at higher concentrations, by the ions of inorganic salts structurally unrelated to NADPH. Hence, electrostatic forces of attraction between charged groups on the coenzyme and the enzyme appear to have an important role in maintaining enzyme-coenzyme association." @default.
- W1529599013 created "2016-06-24" @default.
- W1529599013 creator A5017506642 @default.
- W1529599013 creator A5029059671 @default.
- W1529599013 date "1971-02-01" @default.
- W1529599013 modified "2023-09-29" @default.
- W1529599013 title "Mechanism of Binding of Reduced Nicotinamide Adenine Dinucleotide Phosphate to Vertebrate Fatty Acid Synthetases" @default.
- W1529599013 cites W128699936 @default.
- W1529599013 cites W134503978 @default.
- W1529599013 cites W1488030047 @default.
- W1529599013 cites W1504606556 @default.
- W1529599013 cites W158978002 @default.
- W1529599013 cites W1997298383 @default.
- W1529599013 cites W2004718659 @default.
- W1529599013 cites W2042469368 @default.
- W1529599013 cites W2054662884 @default.
- W1529599013 cites W2055666151 @default.
- W1529599013 cites W2062410652 @default.
- W1529599013 cites W2068301028 @default.
- W1529599013 cites W2332115593 @default.
- W1529599013 doi "https://doi.org/10.1016/s0021-9258(18)62462-7" @default.
- W1529599013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5542678" @default.
- W1529599013 hasPublicationYear "1971" @default.
- W1529599013 type Work @default.
- W1529599013 sameAs 1529599013 @default.
- W1529599013 citedByCount "14" @default.
- W1529599013 countsByYear W15295990132015 @default.
- W1529599013 countsByYear W15295990132018 @default.
- W1529599013 countsByYear W15295990132019 @default.
- W1529599013 crossrefType "journal-article" @default.
- W1529599013 hasAuthorship W1529599013A5017506642 @default.
- W1529599013 hasAuthorship W1529599013A5029059671 @default.
- W1529599013 hasBestOaLocation W15295990131 @default.
- W1529599013 hasConcept C181199279 @default.
- W1529599013 hasConcept C185592680 @default.
- W1529599013 hasConcept C197957613 @default.
- W1529599013 hasConcept C2776568683 @default.
- W1529599013 hasConcept C2776706248 @default.
- W1529599013 hasConcept C2777989768 @default.
- W1529599013 hasConcept C2779728014 @default.
- W1529599013 hasConcept C38485361 @default.
- W1529599013 hasConcept C515207424 @default.
- W1529599013 hasConcept C55493867 @default.
- W1529599013 hasConcept C71240020 @default.
- W1529599013 hasConcept C75520062 @default.
- W1529599013 hasConceptScore W1529599013C181199279 @default.
- W1529599013 hasConceptScore W1529599013C185592680 @default.
- W1529599013 hasConceptScore W1529599013C197957613 @default.
- W1529599013 hasConceptScore W1529599013C2776568683 @default.
- W1529599013 hasConceptScore W1529599013C2776706248 @default.
- W1529599013 hasConceptScore W1529599013C2777989768 @default.
- W1529599013 hasConceptScore W1529599013C2779728014 @default.
- W1529599013 hasConceptScore W1529599013C38485361 @default.
- W1529599013 hasConceptScore W1529599013C515207424 @default.
- W1529599013 hasConceptScore W1529599013C55493867 @default.
- W1529599013 hasConceptScore W1529599013C71240020 @default.
- W1529599013 hasConceptScore W1529599013C75520062 @default.
- W1529599013 hasIssue "3" @default.
- W1529599013 hasLocation W15295990131 @default.
- W1529599013 hasOpenAccess W1529599013 @default.
- W1529599013 hasPrimaryLocation W15295990131 @default.
- W1529599013 hasRelatedWork W1488030047 @default.
- W1529599013 hasRelatedWork W1504606556 @default.
- W1529599013 hasRelatedWork W1572813031 @default.
- W1529599013 hasRelatedWork W1578868227 @default.
- W1529599013 hasRelatedWork W1598458336 @default.
- W1529599013 hasRelatedWork W1963658028 @default.
- W1529599013 hasRelatedWork W1970282770 @default.
- W1529599013 hasRelatedWork W1975877705 @default.
- W1529599013 hasRelatedWork W1979745126 @default.
- W1529599013 hasRelatedWork W1997298383 @default.
- W1529599013 hasRelatedWork W2000635246 @default.
- W1529599013 hasRelatedWork W2013592789 @default.
- W1529599013 hasRelatedWork W2026265496 @default.
- W1529599013 hasRelatedWork W2057317771 @default.
- W1529599013 hasRelatedWork W2062410652 @default.
- W1529599013 hasRelatedWork W2068230596 @default.
- W1529599013 hasRelatedWork W2075499997 @default.
- W1529599013 hasRelatedWork W2077226144 @default.
- W1529599013 hasRelatedWork W2128541897 @default.
- W1529599013 hasRelatedWork W2135458725 @default.
- W1529599013 hasVolume "246" @default.
- W1529599013 isParatext "false" @default.
- W1529599013 isRetracted "false" @default.
- W1529599013 magId "1529599013" @default.
- W1529599013 workType "article" @default.