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- W152963702 abstract "The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the sender mice that received electric shocks on the feet and responded by squealing and jumping, and the responder mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in responder and sender mice, and by diazepam at a dose of 1 mg/kg, per os, in responder mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam." @default.
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- W152963702 date "1987-12-01" @default.
- W152963702 modified "2023-10-14" @default.
- W152963702 title "Effect of clotiazepam on gastric mucosal lesions produced by conditioned emotional stimuli in mice." @default.
- W152963702 doi "https://doi.org/10.18926/amo/31736" @default.
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