Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529713008> ?p ?o ?g. }
- W1529713008 endingPage "3975" @default.
- W1529713008 startingPage "3964" @default.
- W1529713008 abstract "Ecteinascidin 743 (ET-743, Yondelis) is a clinically approved chemotherapeutic natural product isolated from the Caribbean mangrove tunicate Ecteinascidia turbinata. Researchers have long suspected that a microorganism may be the true producer of the anticancer drug, but its genome has remained elusive due to our inability to culture the bacterium in the laboratory using standard techniques. Here, we sequenced and assembled the complete genome of the ET-743 producer, Candidatus Endoecteinascidia frumentensis, directly from metagenomic DNA isolated from the tunicate. Analysis of the ∼ 631 kb microbial genome revealed strong evidence of an endosymbiotic lifestyle and extreme genome reduction. Phylogenetic analysis suggested that the producer of the anti-cancer drug is taxonomically distinct from other sequenced microorganisms and could represent a new family of Gammaproteobacteria. The complete genome has also greatly expanded our understanding of ET-743 production and revealed new biosynthetic genes dispersed across more than 173 kb of the small genome. The gene cluster's architecture and its preservation demonstrate that the drug is likely essential to the interactions of the microorganism with its mangrove tunicate host. Taken together, these studies elucidate the lifestyle of a unique, and pharmaceutically important microorganism and highlight the wide diversity of bacteria capable of making potent natural products." @default.
- W1529713008 created "2016-06-24" @default.
- W1529713008 creator A5020610727 @default.
- W1529713008 creator A5054121661 @default.
- W1529713008 creator A5058420132 @default.
- W1529713008 creator A5075036643 @default.
- W1529713008 creator A5076833294 @default.
- W1529713008 date "2015-07-21" @default.
- W1529713008 modified "2023-10-08" @default.
- W1529713008 title "Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product <scp>ET</scp>‐743" @default.
- W1529713008 cites W1849166904 @default.
- W1529713008 cites W1913187248 @default.
- W1529713008 cites W1923081896 @default.
- W1529713008 cites W1934400729 @default.
- W1529713008 cites W1936630560 @default.
- W1529713008 cites W1968179480 @default.
- W1529713008 cites W1977385550 @default.
- W1529713008 cites W1977447667 @default.
- W1529713008 cites W1983269096 @default.
- W1529713008 cites W1984688358 @default.
- W1529713008 cites W1985756322 @default.
- W1529713008 cites W1992716708 @default.
- W1529713008 cites W1995202238 @default.
- W1529713008 cites W2006125907 @default.
- W1529713008 cites W2011486440 @default.
- W1529713008 cites W2014438907 @default.
- W1529713008 cites W2018408949 @default.
- W1529713008 cites W2019833246 @default.
- W1529713008 cites W2020585685 @default.
- W1529713008 cites W2022793517 @default.
- W1529713008 cites W2025020367 @default.
- W1529713008 cites W2029838231 @default.
- W1529713008 cites W2040163542 @default.
- W1529713008 cites W2044362413 @default.
- W1529713008 cites W2061418578 @default.
- W1529713008 cites W2061575722 @default.
- W1529713008 cites W2063888525 @default.
- W1529713008 cites W2064306419 @default.
- W1529713008 cites W2065814616 @default.
- W1529713008 cites W2067813585 @default.
- W1529713008 cites W2073348815 @default.
- W1529713008 cites W2073555436 @default.
- W1529713008 cites W2075963109 @default.
- W1529713008 cites W2078969200 @default.
- W1529713008 cites W2087576640 @default.
- W1529713008 cites W2088417711 @default.
- W1529713008 cites W2092604303 @default.
- W1529713008 cites W2094402554 @default.
- W1529713008 cites W2095882827 @default.
- W1529713008 cites W2107758049 @default.
- W1529713008 cites W2115453787 @default.
- W1529713008 cites W2118780226 @default.
- W1529713008 cites W2119585200 @default.
- W1529713008 cites W2122197684 @default.
- W1529713008 cites W2127303481 @default.
- W1529713008 cites W2128777911 @default.
- W1529713008 cites W2132020588 @default.
- W1529713008 cites W2137896807 @default.
- W1529713008 cites W2145974700 @default.
- W1529713008 cites W2150570211 @default.
- W1529713008 cites W2158804744 @default.
- W1529713008 cites W2158949802 @default.
- W1529713008 cites W2163685688 @default.
- W1529713008 cites W2165890496 @default.
- W1529713008 cites W2176371198 @default.
- W1529713008 cites W2615139755 @default.
- W1529713008 doi "https://doi.org/10.1111/1462-2920.12908" @default.
- W1529713008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618771" @default.
- W1529713008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26013440" @default.
- W1529713008 hasPublicationYear "2015" @default.
- W1529713008 type Work @default.
- W1529713008 sameAs 1529713008 @default.
- W1529713008 citedByCount "71" @default.
- W1529713008 countsByYear W15297130082015 @default.
- W1529713008 countsByYear W15297130082016 @default.
- W1529713008 countsByYear W15297130082017 @default.
- W1529713008 countsByYear W15297130082018 @default.
- W1529713008 countsByYear W15297130082019 @default.
- W1529713008 countsByYear W15297130082020 @default.
- W1529713008 countsByYear W15297130082021 @default.
- W1529713008 countsByYear W15297130082022 @default.
- W1529713008 countsByYear W15297130082023 @default.
- W1529713008 crossrefType "journal-article" @default.
- W1529713008 hasAuthorship W1529713008A5020610727 @default.
- W1529713008 hasAuthorship W1529713008A5054121661 @default.
- W1529713008 hasAuthorship W1529713008A5058420132 @default.
- W1529713008 hasAuthorship W1529713008A5075036643 @default.
- W1529713008 hasAuthorship W1529713008A5076833294 @default.
- W1529713008 hasBestOaLocation W15297130082 @default.
- W1529713008 hasConcept C104317684 @default.
- W1529713008 hasConcept C141231307 @default.
- W1529713008 hasConcept C15151743 @default.
- W1529713008 hasConcept C175605896 @default.
- W1529713008 hasConcept C18903297 @default.
- W1529713008 hasConcept C193252679 @default.
- W1529713008 hasConcept C2776989901 @default.
- W1529713008 hasConcept C2779396153 @default.
- W1529713008 hasConcept C2780930470 @default.