Matches in SemOpenAlex for { <https://semopenalex.org/work/W1529724399> ?p ?o ?g. }
- W1529724399 endingPage "1401" @default.
- W1529724399 startingPage "1391" @default.
- W1529724399 abstract "Extensive in vitro and in vivo studies have shown that cannabinoid drugs have neuroprotective properties and suggested that the endocannabinoid system may be involved in endogenous neuroprotective mechanisms. On the other hand, neurotoxic effects of cannabinoids in vitro and in vivo were also described. Several possible explanations for these dual, opposite effects of cannabinoids on cellular fate were suggested, and it is conceivable that various factors may determine the final outcome of the cannabinoid effect in vivo. In the current review, we focus on one of the possible reasons for the dual neuroprotective/neurotoxic effects of cannabinoids in vivo, namely, the opposite effects of low versus high doses of cannabinoids. While many studies reported neuroprotective effects of the conventional doses of cannabinoids in various experimental models for acute brain injuries, we have shown that a single administration of an extremely low dose of Δ(9) -tetrahydrocannabinol (THC) (3-4 orders of magnitude lower than the conventional doses) to mice induced long-lasting mild cognitive deficits that affected various aspects of memory and learning. These findings led to the idea that this low dose of THC, which induces minor damage to the brain, may activate preconditioning and/or postconditioning mechanisms and thus will protect the brain from more severe insults. Indeed, our recent findings support this assumption and show that a pre- or a postconditioning treatment with extremely low doses of THC, several days before or after brain injury, provides effective long-term cognitive neuroprotection. The future therapeutical potential of these findings is discussed." @default.
- W1529724399 created "2016-06-24" @default.
- W1529724399 creator A5003504554 @default.
- W1529724399 creator A5023759426 @default.
- W1529724399 creator A5034907298 @default.
- W1529724399 creator A5046284239 @default.
- W1529724399 creator A5069158259 @default.
- W1529724399 date "2011-07-12" @default.
- W1529724399 modified "2023-10-18" @default.
- W1529724399 title "The dual neuroprotective-neurotoxic profile of cannabinoid drugs" @default.
- W1529724399 cites W111663151 @default.
- W1529724399 cites W1253199717 @default.
- W1529724399 cites W1524310794 @default.
- W1529724399 cites W1548409859 @default.
- W1529724399 cites W1579457988 @default.
- W1529724399 cites W1599780098 @default.
- W1529724399 cites W1600905676 @default.
- W1529724399 cites W1608104892 @default.
- W1529724399 cites W1746022025 @default.
- W1529724399 cites W1874385193 @default.
- W1529724399 cites W1904415054 @default.
- W1529724399 cites W1910892416 @default.
- W1529724399 cites W1949541784 @default.
- W1529724399 cites W1965479899 @default.
- W1529724399 cites W1965833191 @default.
- W1529724399 cites W1967716137 @default.
- W1529724399 cites W1967922769 @default.
- W1529724399 cites W1972820094 @default.
- W1529724399 cites W1973645562 @default.
- W1529724399 cites W1974868471 @default.
- W1529724399 cites W1979800361 @default.
- W1529724399 cites W1979911708 @default.
- W1529724399 cites W1980944036 @default.
- W1529724399 cites W1981677003 @default.
- W1529724399 cites W1982170765 @default.
- W1529724399 cites W1982245441 @default.
- W1529724399 cites W1982604009 @default.
- W1529724399 cites W1984305956 @default.
- W1529724399 cites W1984599488 @default.
- W1529724399 cites W1985579470 @default.
- W1529724399 cites W1986003147 @default.
- W1529724399 cites W1987823843 @default.
- W1529724399 cites W1988090725 @default.
- W1529724399 cites W1988633934 @default.
- W1529724399 cites W1989846518 @default.
- W1529724399 cites W1993946115 @default.
- W1529724399 cites W1995208376 @default.
- W1529724399 cites W1996062801 @default.
- W1529724399 cites W1996501597 @default.
- W1529724399 cites W1997291878 @default.
- W1529724399 cites W1997374895 @default.
- W1529724399 cites W1997410543 @default.
- W1529724399 cites W1998532089 @default.
- W1529724399 cites W1999958184 @default.
- W1529724399 cites W2001040242 @default.
- W1529724399 cites W2002381191 @default.
- W1529724399 cites W2004026924 @default.
- W1529724399 cites W2006759122 @default.
- W1529724399 cites W2008146947 @default.
- W1529724399 cites W2009812062 @default.
- W1529724399 cites W2009835870 @default.
- W1529724399 cites W2010980945 @default.
- W1529724399 cites W2011161535 @default.
- W1529724399 cites W2013027611 @default.
- W1529724399 cites W2013990055 @default.
- W1529724399 cites W2015670274 @default.
- W1529724399 cites W2015953188 @default.
- W1529724399 cites W2017443598 @default.
- W1529724399 cites W2017730736 @default.
- W1529724399 cites W2018098811 @default.
- W1529724399 cites W2018953051 @default.
- W1529724399 cites W2024335876 @default.
- W1529724399 cites W2027072784 @default.
- W1529724399 cites W2028794471 @default.
- W1529724399 cites W2029439671 @default.
- W1529724399 cites W2030623240 @default.
- W1529724399 cites W2032715486 @default.
- W1529724399 cites W2032715817 @default.
- W1529724399 cites W2034306131 @default.
- W1529724399 cites W2034657120 @default.
- W1529724399 cites W2036091286 @default.
- W1529724399 cites W2042530543 @default.
- W1529724399 cites W2048306858 @default.
- W1529724399 cites W2050815543 @default.
- W1529724399 cites W2053070543 @default.
- W1529724399 cites W2056330379 @default.
- W1529724399 cites W2058955046 @default.
- W1529724399 cites W2060589571 @default.
- W1529724399 cites W2061224243 @default.
- W1529724399 cites W2063175209 @default.
- W1529724399 cites W2065838665 @default.
- W1529724399 cites W2065987181 @default.
- W1529724399 cites W2066867479 @default.
- W1529724399 cites W2068391993 @default.
- W1529724399 cites W2070287777 @default.
- W1529724399 cites W2070834797 @default.
- W1529724399 cites W2071271032 @default.
- W1529724399 cites W2072079702 @default.