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- W1530034424 abstract "Update on Cimicifuga Racemosa – New Findings from Science and Research: Differentiated Evidence for Efficacy and Safety of Cimicifuga Racemosa Herbal Medicinal Products for Treatment of Climacteric Complaints. Among the phytotherapeutics used for treating climacteric complaints, black cohosh (Cimicifuga racemosa, Actaea racemosa) is best documented. The monograph of the Herbal Medicinal Product Committee of the European Medicines Agency confi rms a positive benefi t-risk ratio of herbal medicinal products from Cimicifuga racemosa (CR). The prerequisite is their production according to GMP criteria with approved pharmaceutical quality. An updated meta-analysis, considering all appropriate randomized controlled trials (RCTs), shows CR to be signifi cantly more effective in ameliorating menopausal symptoms than placebo. Another up-todate review on the effi cacy and safety of CR for climacteric complaints differentiates for the fi rst time between extracts, their quality (refl ected in a regulatory status as medicinal product), and indication – thus meeting the requirements of the system’s logic of phytotherapy. All CR extracts examined in clinical studies demonstrated to be safe and well tolerable. However, only high-quality, registered CR medicinal products were able to demonstrate their effi cacy and a positive benefi t-risk profi le. Consistent confi rmatory evidence of Oxford Level of Evidence 1 and Grade of Recommendation A was provided only by the special isopropanolic CR extract (iCR), which has been examined in numerous studies and > 11,000 patients. J Gynakol Endokrinol 2014; 24 (4): 6–10." @default.
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- W1530034424 date "2014-11-20" @default.
- W1530034424 modified "2023-09-26" @default.
- W1530034424 title "Update Cimicifuga racemosa – neue Erkenntnisse aus Wissenschaft und Forschung: Differenzierte Evidenz für Wirksamkeit und Sicherheit von Traubensilberkerzen-Arzneimitteln zur Behandlung klimakterischer Beschwerden" @default.
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