Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530149822> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1530149822 endingPage "5674" @default.
- W1530149822 startingPage "5666" @default.
- W1530149822 abstract "Abstract Recombinant murine IL-4 and IL-10 have been used in two models of inflammatory lung injury in rats after intrapulmonary deposition of IgG or IgA immune complexes. These models have contrasting requirements for cytokines, phagocytic cells, and adhesion molecules. In these two models of lung injury, IL-4 and IL-10 were individually coinstilled into the airways with the IgG or IgA antibodies, whereas the Ag were injected intravenously. Injury was quantitated by increases in permeability (leakage of 125I-BSA) and by hemorrhage (extravasation of 51Cr-RBC). In the model of IgG immune complex-induced lung injury, IL-4 and IL-10 were each highly protective when given in nanogram amounts. These protective effects were dose dependent. IL-4 and IL-10 caused substantial reductions in lung content of myeloperoxidase and parallel reductions in neutrophil content in bronchoalveolar lavage (BAL) fluids. The protective effects of IL-4 and IL-10 were associated with profound reductions of TNF-alpha in the BAL fluids and complete inhibition in the up-regulation of pulmonary vascular ICAM-1. In the IgA immune complex model of lung injury IL-4 had no protective effects, whereas IL-10 was highly protective. These protective effects correlated with diminished retrieval of alveolar macrophages in BAL fluids. These data suggest that IL-4 and IL-10 have significant protective effects in lung inflammatory injury, presumably achieving these effects by various mechanisms." @default.
- W1530149822 created "2016-06-24" @default.
- W1530149822 creator A5021126684 @default.
- W1530149822 creator A5026915262 @default.
- W1530149822 creator A5042966626 @default.
- W1530149822 creator A5049826084 @default.
- W1530149822 creator A5055689637 @default.
- W1530149822 date "1993-11-15" @default.
- W1530149822 modified "2023-10-17" @default.
- W1530149822 title "Protective effects of IL-4 and IL-10 against immune complex-induced lung injury." @default.
- W1530149822 doi "https://doi.org/10.4049/jimmunol.151.10.5666" @default.
- W1530149822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7901280" @default.
- W1530149822 hasPublicationYear "1993" @default.
- W1530149822 type Work @default.
- W1530149822 sameAs 1530149822 @default.
- W1530149822 citedByCount "116" @default.
- W1530149822 countsByYear W15301498222012 @default.
- W1530149822 countsByYear W15301498222013 @default.
- W1530149822 countsByYear W15301498222014 @default.
- W1530149822 countsByYear W15301498222015 @default.
- W1530149822 countsByYear W15301498222016 @default.
- W1530149822 countsByYear W15301498222017 @default.
- W1530149822 countsByYear W15301498222019 @default.
- W1530149822 countsByYear W15301498222020 @default.
- W1530149822 countsByYear W15301498222022 @default.
- W1530149822 crossrefType "journal-article" @default.
- W1530149822 hasAuthorship W1530149822A5021126684 @default.
- W1530149822 hasAuthorship W1530149822A5026915262 @default.
- W1530149822 hasAuthorship W1530149822A5042966626 @default.
- W1530149822 hasAuthorship W1530149822A5049826084 @default.
- W1530149822 hasAuthorship W1530149822A5055689637 @default.
- W1530149822 hasBestOaLocation W15301498221 @default.
- W1530149822 hasConcept C126322002 @default.
- W1530149822 hasConcept C159654299 @default.
- W1530149822 hasConcept C17991360 @default.
- W1530149822 hasConcept C203014093 @default.
- W1530149822 hasConcept C203565725 @default.
- W1530149822 hasConcept C2776914184 @default.
- W1530149822 hasConcept C2777714996 @default.
- W1530149822 hasConcept C2777961210 @default.
- W1530149822 hasConcept C2778474638 @default.
- W1530149822 hasConcept C2779540182 @default.
- W1530149822 hasConcept C71924100 @default.
- W1530149822 hasConcept C8891405 @default.
- W1530149822 hasConceptScore W1530149822C126322002 @default.
- W1530149822 hasConceptScore W1530149822C159654299 @default.
- W1530149822 hasConceptScore W1530149822C17991360 @default.
- W1530149822 hasConceptScore W1530149822C203014093 @default.
- W1530149822 hasConceptScore W1530149822C203565725 @default.
- W1530149822 hasConceptScore W1530149822C2776914184 @default.
- W1530149822 hasConceptScore W1530149822C2777714996 @default.
- W1530149822 hasConceptScore W1530149822C2777961210 @default.
- W1530149822 hasConceptScore W1530149822C2778474638 @default.
- W1530149822 hasConceptScore W1530149822C2779540182 @default.
- W1530149822 hasConceptScore W1530149822C71924100 @default.
- W1530149822 hasConceptScore W1530149822C8891405 @default.
- W1530149822 hasIssue "10" @default.
- W1530149822 hasLocation W15301498221 @default.
- W1530149822 hasLocation W15301498222 @default.
- W1530149822 hasOpenAccess W1530149822 @default.
- W1530149822 hasPrimaryLocation W15301498221 @default.
- W1530149822 hasRelatedWork W1530149822 @default.
- W1530149822 hasRelatedWork W2028350325 @default.
- W1530149822 hasRelatedWork W2050707064 @default.
- W1530149822 hasRelatedWork W2055533250 @default.
- W1530149822 hasRelatedWork W2063143252 @default.
- W1530149822 hasRelatedWork W2067934824 @default.
- W1530149822 hasRelatedWork W2072196714 @default.
- W1530149822 hasRelatedWork W2091299039 @default.
- W1530149822 hasRelatedWork W2160869739 @default.
- W1530149822 hasRelatedWork W2905245425 @default.
- W1530149822 hasVolume "151" @default.
- W1530149822 isParatext "false" @default.
- W1530149822 isRetracted "false" @default.
- W1530149822 magId "1530149822" @default.
- W1530149822 workType "article" @default.