FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530221331> ?p ?o ?g. }

• W1530221331 endingPage "788" @default.
• W1530221331 startingPage "785" @default.
• W1530221331 abstract "1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determined after 5 weeks of sustained hyperglycaemia. Blood flow was greater and was also redistributed in the diabetic group compared with values for the control group. At the same time, oxygen tension distribution was altered around retinal arterioles, implying an increase in retinal oxygen consumption in these early diabetic retinas. 3. The possibility that the blood flow changes could be due to altered control mechanisms in the retinal vasculature was confirmed using an isolated, perfused eye preparation. In diabetic eyes an altered reactivity to test pharmacological agents was demonstrated after 4 weeks of diabetes. 4. To further explore these vascular response changes we developed an isolated, perfused retinal arteriolar preparation in which individual segments of the vasculature can be tested. The possibility that insulin has a direct vasodilator effect on retinal arterioles was confirmed and was demonstrated to act via nitric oxide released from the vascular endothelial cells. These data may implicate the diabetic-induced insulin changes in early retinal changes. 5. Evidence is presented that although early glucose control may be vital in stopping the onset of diabetic retinopathy, there comes a stage in the induced diabetic cascade where if the retinopathy has commenced, good glucose control cannot stop the further progression of the retinopathy." @default.
• W1530221331 created "2016-06-24" @default.
• W1530221331 creator A5019118578 @default.
• W1530221331 creator A5032144691 @default.
• W1530221331 creator A5046421294 @default.
• W1530221331 creator A5056140843 @default.
• W1530221331 creator A5060945875 @default.
• W1530221331 date "1997-10-01" @default.
• W1530221331 modified "2023-10-12" @default.
• W1530221331 title "DIABETIC RETINOPATHY: EARLY FUNCTIONAL CHANGES." @default.
• W1530221331 cites W1966150597 @default.
• W1530221331 cites W2015958773 @default.
• W1530221331 cites W2034384804 @default.
• W1530221331 cites W2042120831 @default.
• W1530221331 cites W2049442652 @default.
• W1530221331 cites W2056182908 @default.
• W1530221331 cites W2058551274 @default.
• W1530221331 cites W2065508054 @default.
• W1530221331 cites W2069777058 @default.
• W1530221331 cites W2072491658 @default.
• W1530221331 cites W2086204342 @default.
• W1530221331 cites W2090555030 @default.
• W1530221331 cites W2124755357 @default.
• W1530221331 cites W2166982363 @default.
• W1530221331 cites W4241612639 @default.
• W1530221331 doi "https://doi.org/10.1111/j.1440-1681.1997.tb02133.x" @default.
• W1530221331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9315390" @default.
• W1530221331 hasPublicationYear "1997" @default.
• W1530221331 type Work @default.
• W1530221331 sameAs 1530221331 @default.
• W1530221331 citedByCount "87" @default.
• W1530221331 countsByYear W15302213312012 @default.
• W1530221331 countsByYear W15302213312013 @default.
• W1530221331 countsByYear W15302213312014 @default.
• W1530221331 countsByYear W15302213312015 @default.
• W1530221331 countsByYear W15302213312016 @default.
• W1530221331 countsByYear W15302213312017 @default.
• W1530221331 countsByYear W15302213312018 @default.
• W1530221331 countsByYear W15302213312019 @default.
• W1530221331 countsByYear W15302213312020 @default.
• W1530221331 countsByYear W15302213312021 @default.
• W1530221331 countsByYear W15302213312022 @default.
• W1530221331 countsByYear W15302213312023 @default.
• W1530221331 crossrefType "journal-article" @default.
• W1530221331 hasAuthorship W1530221331A5019118578 @default.
• W1530221331 hasAuthorship W1530221331A5032144691 @default.
• W1530221331 hasAuthorship W1530221331A5046421294 @default.
• W1530221331 hasAuthorship W1530221331A5056140843 @default.
• W1530221331 hasAuthorship W1530221331A5060945875 @default.
• W1530221331 hasConcept C118487528 @default.
• W1530221331 hasConcept C120770815 @default.
• W1530221331 hasConcept C126322002 @default.
• W1530221331 hasConcept C134018914 @default.
• W1530221331 hasConcept C169760540 @default.
• W1530221331 hasConcept C178790620 @default.
• W1530221331 hasConcept C185592680 @default.
• W1530221331 hasConcept C2776513394 @default.
• W1530221331 hasConcept C2777093970 @default.
• W1530221331 hasConcept C2778313320 @default.
• W1530221331 hasConcept C2779306644 @default.
• W1530221331 hasConcept C2779829184 @default.
• W1530221331 hasConcept C2780827179 @default.
• W1530221331 hasConcept C2993207723 @default.
• W1530221331 hasConcept C519581460 @default.
• W1530221331 hasConcept C540031477 @default.
• W1530221331 hasConcept C555293320 @default.
• W1530221331 hasConcept C71924100 @default.
• W1530221331 hasConcept C86803240 @default.
• W1530221331 hasConceptScore W1530221331C118487528 @default.
• W1530221331 hasConceptScore W1530221331C120770815 @default.
• W1530221331 hasConceptScore W1530221331C126322002 @default.
• W1530221331 hasConceptScore W1530221331C134018914 @default.
• W1530221331 hasConceptScore W1530221331C169760540 @default.
• W1530221331 hasConceptScore W1530221331C178790620 @default.
• W1530221331 hasConceptScore W1530221331C185592680 @default.
• W1530221331 hasConceptScore W1530221331C2776513394 @default.
• W1530221331 hasConceptScore W1530221331C2777093970 @default.
• W1530221331 hasConceptScore W1530221331C2778313320 @default.
• W1530221331 hasConceptScore W1530221331C2779306644 @default.
• W1530221331 hasConceptScore W1530221331C2779829184 @default.
• W1530221331 hasConceptScore W1530221331C2780827179 @default.
• W1530221331 hasConceptScore W1530221331C2993207723 @default.
• W1530221331 hasConceptScore W1530221331C519581460 @default.
• W1530221331 hasConceptScore W1530221331C540031477 @default.
• W1530221331 hasConceptScore W1530221331C555293320 @default.
• W1530221331 hasConceptScore W1530221331C71924100 @default.
• W1530221331 hasConceptScore W1530221331C86803240 @default.
• W1530221331 hasIssue "9-10" @default.
• W1530221331 hasLocation W15302213311 @default.
• W1530221331 hasLocation W15302213312 @default.
• W1530221331 hasOpenAccess W1530221331 @default.
• W1530221331 hasPrimaryLocation W15302213311 @default.
• W1530221331 hasRelatedWork W110576239 @default.
• W1530221331 hasRelatedWork W1124841833 @default.
• W1530221331 hasRelatedWork W1530221331 @default.
• W1530221331 hasRelatedWork W2041483920 @default.
• W1530221331 hasRelatedWork W2073436318 @default.
• W1530221331 hasRelatedWork W2579905261 @default.

• next