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• W1530296779 abstract "Article1 October 1942A FURTHER REPORT ON THE TREATMENT OF ADDISON'S DISEASE WITH DESOXYCORTICOSTERONE ACETATE BY INTRAMUSCULAR INJECTIONS, SUBCUTANEOUS IMPLANTATION OF PELLETS, AND SUBLINGUAL ADMINISTRATIONFRANK L. ENGEL, M.D., CLARENCE COHN, M.D., LOUIS J. SOFFER, M.D.FRANK L. ENGEL, M.D.Search for more papers by this author, CLARENCE COHN, M.D.Search for more papers by this author, LOUIS J. SOFFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-4-585 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the original reports by Levy-Simpson1and Thorn2, 3, 4on the use of desoxycorticosterone acetate in the treatment of Addison's disease, many further reports have appeared confirming its value and pointing out its limitations and toxic effects resulting from overdosage.5, 6, 7In 1939 an advance in therapy was made by Thorn and his co-workers8, 9who utilized the technic of Deanesly and Parkes10and maintained adrenalectomized dogs and patients with Addison's disease in good condition by implantation of pellets of crystalline desoxycorticosterone acetate subcutaneously. By this method a slow and steady release of hormone, calculated at about 0.2...Bibliography1. LEVY-SIMPSON S: The use of synthetic desoxycorticosterone acetate in Addison's disease, Lancet, 1938, ii, 557. CrossrefGoogle Scholar2. THORNENGELEISENBERG GWLLH: The effect of corticosterone and related compounds on the renal excretion of electrolytes, Jr. Exper. Med., 1938, lxviii, 161. CrossrefGoogle Scholar3. THORNEISENBERG GWH: Studies on desoxycorticosterone, a synthetic adrenal cortical hormone, Endocrinology, 1939, xxv, 39. CrossrefGoogle Scholar4. THORNHOWARDEMERSON GWRPK: Treatment of Addison's disease with desoxycorticosterone acetate, a synthetic adrenal cortical hormone, Jr. Clin. Invest., 1939, xviii, 449. CrossrefGoogle Scholar5. FERREBEERAGANATCHLEYLOEB JWCDWRF: Desoxycorticosterone esters: certain effects in the treatment of Addison's disease, Jr. Am. Med. Assoc., 1939, cxiii, 1725. Google Scholar6. CLEGHORNFOWLERWENZEL RAJLJS: The treatment of Addison's disease by a synthetic adrenal cortical hormone, Canad. Med. Assoc. Jr., 1939, xli, 226. Google Scholar7. THADDEASARKANDER SH: Über die Wirkung des synthetischen Nebennierenrindenhormons bei klinischer Nebenniereninsuffizienz, Ztschr. f. klin. Med., 1939, cxxxvi, 267. Google Scholar8. THORNENGELEISENBERG GWLLH: Treatment of adrenal insufficiency by means of subcutaneous implant of pellets of desoxycorticosterone acetate (a synthetic adrenal cortical hormone), Bull. Johns Hopkins Hosp., 1939, lxiv, 155. Google Scholar9. THORNEMERSONFIROR GWKWM: Treatment of Addison's disease with pellets of crystalline adrenal cortical hormone implanted subcutaneously, Ibid., 1939, liv, 339. Google Scholar10. DEANESLYPARKES RAS: Factors influencing the effectiveness of administered hormones, Proc. Roy. Soc. London, S. B., 1937, cxxiv, 279. Further experiments on the administration of hormones by the subcutaneous implantation of pellets, Lancet, 1938, ii, 606. Google Scholar11. RYANMCCULLOGH EJEP: Desoxycorticosterone acetate in Addison's disease, Cleveland Clin. Quart., 1940, vii, 19. CrossrefGoogle Scholar12. SOFFERENGELOPPENHEIMER LJFLBS: Treatment of Addison's disease with desoxycorticosterone acetate by intramuscular injections and subcutaneous implantation of pellets, Jr. Am. Med. Assoc., 1940, cxv, 1560. Google Scholar13. SEGALL G: Treatment of Addison's disease with pellets of synthetic desoxycorticosterone acetate implanted subcutaneously, Am. Jr. Med. Sci., 1941, cci, 202. CrossrefGoogle Scholar14. THORNFIROR GWWM: Desoxycorticosterone acetate therapy in Addison's disease, Jr. Am. Med. Assoc., 1940, cxiv, 2517. Google Scholar15. THORN GW: The treatment of Addison's disease, Clin. Endocrinology, 1941, i, 76. CrossrefGoogle Scholar16. ANDERSONHAYMAKERHENDERSON EWE: Successful sublingual therapy in Addison's disease, Jr. Am. Med. Assoc., 1940, cxv, 2167. CrossrefGoogle Scholar17. TURNOFFROWNTREE DLG: Successful sublingual therapy in Addison's disease, Jr. Am. Med. Assoc., 1941, cxvi, 2016. CrossrefGoogle Scholar18. WILLSONRYNEARSONDRY OMEHTJ: Cardiac failure following treatment of Addison's disease with desoxycorticosterone acetate, Proc. Staff Meet. Mayo Clin., 1941, xvi, 168. Google Scholar19. WILDER RM: Progress in the treatment of Addison's disease, Proc. Staff Meet. Mayo Clin., 1940, xv, 273. Google Scholar20. TOOKEPOWERKEPLER TBMHEJ: Tolerance for potassium of patients with Addison's disease treated with desoxycorticosterone acetate, Proc. Staff Meet. Mayo Clin., 1940, xv, 365. Google Scholar21. KUHLMANNRAGANFERRABEEATCHLEYLOEB DCJWDWRF: Toxic effects of desoxycorticosterone esters in dogs, Science, 1939, xc, 496. CrossrefGoogle Scholar22. FERREBEERAGANATCHLEYLOEB JWCDWRF: Comparison of desoxycorticosterone, corticosterone and cortical extract in the treatment of a patient with Addison's disease, Endocrinology, 1940, xxvii, 360. CrossrefGoogle Scholar23. THORNKOEPFLEWISOLSEN GWGFRAEF: Carbohydrate metabolism in Addison's disease, Jr. Clin. Invest., 1940, xix, 813. CrossrefGoogle Scholar24. INGLE DJ: The work performance of adrenalectomized rats treated with corticosterone and related compounds, Endocrinology, 1940, xxvi, 472. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication December 22, 1941.From the Medical Services of The Mount Sinai Hospital, New York City.The desoxycorticosterone acetate (Percorten) was generously supplied and manufactured by the Ciba Pharmaceutical Co., Summit, N. J.†Eugene Meyer, Jr. Fellow. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE DIAGNOSIS AND TREATMENT OF ADDISON'S DISEASEA Study of Sublingual Absorption I. Several Factors Influencing the Rate of Absorption*Die Keimdrüsen und ihre KrankheitenDisturbance in salt and water metabolism in hypertensionThe Absorption of Steroid Hormones from the Oral Mucous Membranes, with Special Reference to the Sublingual Administration of Progesterone 1 October 1942Volume 17, Issue 4Page: 585-603KeywordsHormonesIntramuscular injectionsMedical servicesSubcutaneous injections ePublished: 1 December 2008 Issue Published: 1 October 1942 Copyright & PermissionsCopyright, 1942, by The American College of PhysiciansPDF downloadLoading ..." @default.
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