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• W1530372611 abstract "Article1 March 1948CLINICAL APPRAISAL OF BENADRYL, PYRIBENZAMINE, AND ANTHALLAN IN THE TREATMENT OF ALLERGIC DISORDERSMARTIN S. KLECKNER JR.MARTIN S. KLECKNER JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-3-583 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past year there have been numerous reports of remarkable advances in the treatment of various types of allergic reactions through the use of three drugs in particular which appear to have the action of neutralizing the effects of histamine. I refer to the new antihistamine preparations that have become available: Benadryl, Pyribenzamine, and Anthallan. The therapeutic usefulness of these pharmaceuticals has led to widespread acclaim by the laity, to hundreds of back orders in drug stores, and to exaggerated propaganda by the press and radio. This was particularly true during the dreaded hay-fever season when untold numbers of...Bibliography1. CODE CF: The mechanism of anaphylactic and allergic reactions; an evaluation of the rôle of histamine in their production and allergy, Ann. All., 1944, ii, 457-471. Google Scholar2. CODE CF: A discussion of Benadryl as an antihistamine substance, Proc. Staff Meet. Mayo Clinic, 1945, xx, 439-445. Google Scholar3. BESTTAYLOR : Physiological basis of medical practice, 2nd Edition, 588. Google Scholar4. CECIL : Textbook of medicine, 6th Edition, 457-477. Google Scholar5. LOEWKAISER ERME: Alleviation of anaphylactic shock in guinea pigs with synthetic benzhydryl alkamine ethers, Proc. Soc. Exper. Biol. and Med., 1945, lviii, 235. CrossrefGoogle Scholar6. LOEWKAISERMOORE ERMEV: Synthetic benzhydryl alkamine ethers in preventing fatal experimental asthma in guinea pigs exposed to atomized histamine, Jr. Pharmacol. and Exper. Therap., 1945, lxxxiii, 120. Google Scholar7. 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Direct Communication from Ciba Pharmaceutical Products, Inc., Summit, N. J. Google Scholar25. ARBESMANKOEPFMILLER CEGFGE: Some anti-anaphylactic and antihistamine properties of N-pyridyl, N'benz, dimethylethylene-diamine monohydrochloride (Pyribenzamine), Jr. Allg., 1946, xvii, 203. CrossrefGoogle Scholar26. EPSTEIN S: The clinical experiences of a new anti-histamine compound (Pyribenzamine) in certain cutaneous disorders, Arch. Dermat. and Syph., 1947, lv, 309-321. Wisconsin Med. Jr., 1946, xlv, 489. Google Scholar27. OSBORNEJORDANRAUSCH EDJWNG: Clinical use of a new antihistamine compound (Pyribenzamine) in certain cutaneous disorders, in press. Google Scholar28. Direct Communication from Medico Chemical Corporation of America, New York City, N. Y. Google Scholar29. GHISELIN AD: The treatment of seasonal and non-seasonal hyperesthetic rhinitis with Anthallan, Bull. N. Y. Acad. Med., 1946, xxii, 320. Google Scholar30. Editorial, Jr. Am. Med. Assoc., 1946, ix, 745. Google Scholar31. 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CrossrefGoogle Scholar39. LAKE CF: Rhinitis medicamentosa, Proc. Staff Meet. Mayo Clinic, 1946, xxi, 367-371. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Corps A.U.S. † Allentown, Pennsylvania*Received for publication February 26, 1947.†The author is a fellow-elect in Internal Medicine at the Mayo Foundation, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisturbances of Urination after Administration of Certain Newer DrugsTripelennamine Dysuria in Chronic Nephritic UremiaA Comparison of the Effects of Anthallan, Pyribenzamine, and Epinephrine on Smooth Muscle*†A Summary of the pharmacological and toxico-logical properties of anthallan (3-di(n-butyl)-aminomethyl-4,5,6-trihydroxy-phenylphthalide) 1 March 1948Volume 28, Issue 3Page: 583-597KeywordsAllergy and immunologyAntihistaminesDrugsHistamine Issue Published: 1 March 1948 PDF downloadLoading ..." @default.
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