FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530427417> ?p ?o ?g. }

• W1530427417 endingPage "191" @default.
• W1530427417 startingPage "183" @default.
• W1530427417 abstract "We previously reported that the human keratin 19 (K19) gene was expressed in nonkeratinizing oral epithelial subtypes, and that the steady state K19 mRNA levels in different normal epithelial subtypes correlated with the levels of the retinoic acid receptor (RAR) beta-mRNA (Hu, L., Crowe, D. L., Rheinwald, J. G., Chambon, P., and Gudas, L. J. (1991) Cancer Res. 51, 3972-3981). To elucidate the mechanisms by which the K19 gene is differentially expressed in various epithelial subtypes, we isolated phage containing human K19 genomic DNA from a human placental library. Through transient transfection assays with various K19/CAT constructs that contain different portions of K19 genomic DNA, an enhancer sequence has been identified in the K19 3'-flanking region. In normal human epithelial cell strains, the activity of this enhancer correlates with K19 mRNA abundance. This enhancer activates both the K19 and TK basal promoters in HeLa cells. A high level of K19/CAT fusion mRNA was detected when this K19 3' enhancer sequence was present at the 3' end of the fusion gene whereas no K19/CAT fusion transcript was detected if this 3' K19 enhancer sequence was absent, suggesting that the 3' K19 enhancer is crucial for the positive regulation of K19 expression. Deletion analysis has permitted the localization of the enhancer to a 19-base pair sequence which contains an AP1 binding site (AGTCATCT). Point mutations within this AP1 site completely abolished K19 enhancer activity in HeLa cells. Co-transfections of a c-jun expression vector with K19/CAT reporter constructs demonstrated that c-jun was able to activate the K19 promoter via the 3' K19 enhancer. Collectively, these data indicate that a cis-acting AP1 element and its associated trans-acting effector proteins regulate expression of lineage-specific genes in epithelial cells." @default.
• W1530427417 created "2016-06-24" @default.
• W1530427417 creator A5018083160 @default.
• W1530427417 creator A5033763954 @default.
• W1530427417 date "1994-01-01" @default.
• W1530427417 modified "2023-10-17" @default.
• W1530427417 title "Activation of keratin 19 gene expression by a 3' enhancer containing an AP1 site." @default.
• W1530427417 cites W1575308338 @default.
• W1530427417 cites W1697008857 @default.
• W1530427417 cites W1881047517 @default.
• W1530427417 cites W1944595096 @default.
• W1530427417 cites W1969615929 @default.
• W1530427417 cites W1971624992 @default.
• W1530427417 cites W1981601576 @default.
• W1530427417 cites W1982598173 @default.
• W1530427417 cites W1983851236 @default.
• W1530427417 cites W1986131193 @default.
• W1530427417 cites W1986424647 @default.
• W1530427417 cites W1987897953 @default.
• W1530427417 cites W1996709797 @default.
• W1530427417 cites W1998835611 @default.
• W1530427417 cites W2000371106 @default.
• W1530427417 cites W2008298934 @default.
• W1530427417 cites W2013046038 @default.
• W1530427417 cites W2015177674 @default.
• W1530427417 cites W2016693266 @default.
• W1530427417 cites W2020944732 @default.
• W1530427417 cites W2022708373 @default.
• W1530427417 cites W2028553942 @default.
• W1530427417 cites W2029977444 @default.
• W1530427417 cites W2032944908 @default.
• W1530427417 cites W2033491152 @default.
• W1530427417 cites W2033636301 @default.
• W1530427417 cites W2033652800 @default.
• W1530427417 cites W2036957298 @default.
• W1530427417 cites W2037702964 @default.
• W1530427417 cites W2039548868 @default.
• W1530427417 cites W2042018645 @default.
• W1530427417 cites W2049791242 @default.
• W1530427417 cites W2058217397 @default.
• W1530427417 cites W2058744360 @default.
• W1530427417 cites W2061178138 @default.
• W1530427417 cites W2064245795 @default.
• W1530427417 cites W2066101080 @default.
• W1530427417 cites W2066144226 @default.
• W1530427417 cites W2068577315 @default.
• W1530427417 cites W2068681523 @default.
• W1530427417 cites W2071137639 @default.
• W1530427417 cites W2071550195 @default.
• W1530427417 cites W2078952292 @default.
• W1530427417 cites W2080360085 @default.
• W1530427417 cites W2081135713 @default.
• W1530427417 cites W2081720324 @default.
• W1530427417 cites W2085953550 @default.
• W1530427417 cites W2087811918 @default.
• W1530427417 cites W2089688759 @default.
• W1530427417 cites W2091649522 @default.
• W1530427417 cites W2094341238 @default.
• W1530427417 cites W2097998324 @default.
• W1530427417 cites W2114666742 @default.
• W1530427417 cites W2119226652 @default.
• W1530427417 cites W2122003447 @default.
• W1530427417 cites W2122043314 @default.
• W1530427417 cites W2124551132 @default.
• W1530427417 cites W2135905960 @default.
• W1530427417 cites W2155249371 @default.
• W1530427417 cites W2162424635 @default.
• W1530427417 cites W2166874352 @default.
• W1530427417 cites W2175187053 @default.
• W1530427417 cites W2227731902 @default.
• W1530427417 cites W2289751621 @default.
• W1530427417 cites W2418691345 @default.
• W1530427417 cites W289505252 @default.
• W1530427417 cites W56197667 @default.
• W1530427417 doi "https://doi.org/10.1016/s0021-9258(17)42332-5" @default.
• W1530427417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7506253" @default.
• W1530427417 hasPublicationYear "1994" @default.
• W1530427417 type Work @default.
• W1530427417 sameAs 1530427417 @default.
• W1530427417 citedByCount "37" @default.
• W1530427417 countsByYear W15304274172012 @default.
• W1530427417 countsByYear W15304274172013 @default.
• W1530427417 countsByYear W15304274172014 @default.
• W1530427417 countsByYear W15304274172021 @default.
• W1530427417 countsByYear W15304274172023 @default.
• W1530427417 crossrefType "journal-article" @default.
• W1530427417 hasAuthorship W1530427417A5018083160 @default.
• W1530427417 hasAuthorship W1530427417A5033763954 @default.
• W1530427417 hasBestOaLocation W15304274171 @default.
• W1530427417 hasConcept C102280478 @default.
• W1530427417 hasConcept C104317684 @default.
• W1530427417 hasConcept C111936080 @default.
• W1530427417 hasConcept C150194340 @default.
• W1530427417 hasConcept C153911025 @default.
• W1530427417 hasConcept C185592680 @default.
• W1530427417 hasConcept C54355233 @default.
• W1530427417 hasConcept C81241287 @default.
• W1530427417 hasConcept C86803240 @default.

• next