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- W1530467314 abstract "Background To evaluate the usefulness of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by pretreatment fluorine 18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) as predictors of clinical outcome in hypopharyngeal squamous cell carcinoma (HPSCC). Methods Seventy-eight patients with HPSCC treated with definitive radiotherapy with or without chemotherapy underwent 18F-FDG PET/CT. Maximum standardized uptake value (SUVmax), MTV, and TLG were measured. For calculation of MTV, 3-D regions of interest were drawn and a SUV threshold of 2.5 was used for defining region. Univariate and multivariate analyses identified variables associated with disease-free survival (DFS) and overall survival (OS). Results Median SUVmax, MTV, and TLG were 9.0 (range, 1.7–24.5), 20.5 (0.3–339.9) ml, and 98.9 (0.8–1877.1) g, respectively. The four-year DFS and OS were 56.1% and 52.6%, respectively. On univariate and multivariate analyses, MTV (P = 0.014) and TLG (P = 0.029) were independent prognostic factors for DFS, and MTV (P = 0.002) and TLG (P = 0.002) were independent prognostic factors for OS. Conclusion MTV and TLG measured by pretreatment 18F-FDG PET/CT may be useful in predicting the clinical outcomes of HPSCC patients undergoing radiotherapy. J. Surg. Oncol. 2014 110:869–875. © 2014 Wiley Periodicals, Inc." @default.
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- W1530467314 date "2014-08-02" @default.
- W1530467314 modified "2023-10-18" @default.
- W1530467314 title "Clinical significance of pretreatment metabolic tumor volume and total lesion glycolysis in hypopharyngeal squamous cell carcinomas" @default.
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- W1530467314 doi "https://doi.org/10.1002/jso.23729" @default.
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