Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530566921> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1530566921 abstract "The process of epithelial-mesenchymal transition (EMT) is important in tissue fibrosis, wound healing and cancer. Transforming growth factor beta (TGF-β) induces EMT and fibrotic proteins in a variety of responsive cells via a mechanism that is not fully understood. This study identifies a critical role of JunB in the EMT and fibrotic process in response to TGF-β. Knock-down of the immediate-early response gene JunB by siRNA abrogates TGF-β-induced disruption of epithelial cell junctions, formation of actin fibers, focal adhesions and expression of fibrotic proteins. JunB contributes to Smad-mediated repression of Id2 helix-loop-helix protein but does not affect the induction of Hmga2, Snail and Slug. Knock-down of JunB abolishes up-regulation of ATF3, which is required for Id2 repression. Importantly, JunB contributes to the TGF-β-induced fibrotic response by regulating expression of fibronectin, fibulin-2, tropomyosin (Tpm1) and β3-integrin, which play critical roles in matrix deposition, cell-matrix adhesion and actin stress-fibers. In summary, JunB provides important input in setting the transcriptional program of the EMT and fibrotic responses to TGF-β. Thus, JunB represents an important target in diseases associated with EMT, including cancer and fibrosis. Grant Funding Source: Supported by R01 CA95263" @default.
- W1530566921 created "2016-06-24" @default.
- W1530566921 creator A5017152694 @default.
- W1530566921 creator A5040890122 @default.
- W1530566921 creator A5050138694 @default.
- W1530566921 creator A5067884449 @default.
- W1530566921 date "2014-04-01" @default.
- W1530566921 modified "2023-09-26" @default.
- W1530566921 title "JunB contributes to the epithelial‐mesenchymal transition in response to TGF‐β (LB277)" @default.
- W1530566921 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb277" @default.
- W1530566921 hasPublicationYear "2014" @default.
- W1530566921 type Work @default.
- W1530566921 sameAs 1530566921 @default.
- W1530566921 citedByCount "0" @default.
- W1530566921 crossrefType "journal-article" @default.
- W1530566921 hasAuthorship W1530566921A5017152694 @default.
- W1530566921 hasAuthorship W1530566921A5040890122 @default.
- W1530566921 hasAuthorship W1530566921A5050138694 @default.
- W1530566921 hasAuthorship W1530566921A5067884449 @default.
- W1530566921 hasConcept C104317684 @default.
- W1530566921 hasConcept C118131993 @default.
- W1530566921 hasConcept C127561419 @default.
- W1530566921 hasConcept C185592680 @default.
- W1530566921 hasConcept C2776364838 @default.
- W1530566921 hasConcept C2781080636 @default.
- W1530566921 hasConcept C2781085546 @default.
- W1530566921 hasConcept C502942594 @default.
- W1530566921 hasConcept C54355233 @default.
- W1530566921 hasConcept C76419328 @default.
- W1530566921 hasConcept C86339819 @default.
- W1530566921 hasConcept C86803240 @default.
- W1530566921 hasConcept C95444343 @default.
- W1530566921 hasConceptScore W1530566921C104317684 @default.
- W1530566921 hasConceptScore W1530566921C118131993 @default.
- W1530566921 hasConceptScore W1530566921C127561419 @default.
- W1530566921 hasConceptScore W1530566921C185592680 @default.
- W1530566921 hasConceptScore W1530566921C2776364838 @default.
- W1530566921 hasConceptScore W1530566921C2781080636 @default.
- W1530566921 hasConceptScore W1530566921C2781085546 @default.
- W1530566921 hasConceptScore W1530566921C502942594 @default.
- W1530566921 hasConceptScore W1530566921C54355233 @default.
- W1530566921 hasConceptScore W1530566921C76419328 @default.
- W1530566921 hasConceptScore W1530566921C86339819 @default.
- W1530566921 hasConceptScore W1530566921C86803240 @default.
- W1530566921 hasConceptScore W1530566921C95444343 @default.
- W1530566921 hasIssue "S1" @default.
- W1530566921 hasLocation W15305669211 @default.
- W1530566921 hasOpenAccess W1530566921 @default.
- W1530566921 hasPrimaryLocation W15305669211 @default.
- W1530566921 hasRelatedWork W1530566921 @default.
- W1530566921 hasRelatedWork W2128275386 @default.
- W1530566921 hasRelatedWork W2147478932 @default.
- W1530566921 hasRelatedWork W2463587629 @default.
- W1530566921 hasRelatedWork W2482631943 @default.
- W1530566921 hasRelatedWork W2587671682 @default.
- W1530566921 hasRelatedWork W2592457325 @default.
- W1530566921 hasRelatedWork W2605979451 @default.
- W1530566921 hasRelatedWork W3086196372 @default.
- W1530566921 hasRelatedWork W4361824206 @default.
- W1530566921 hasVolume "28" @default.
- W1530566921 isParatext "false" @default.
- W1530566921 isRetracted "false" @default.
- W1530566921 magId "1530566921" @default.
- W1530566921 workType "article" @default.