Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530727937> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1530727937 endingPage "296" @default.
- W1530727937 startingPage "285" @default.
- W1530727937 abstract "Sodium selenite (Na2SeO3) is an anticarcinogenic/antimutagenic/anticlastogenic agent that under certain incubation conditions induces sister-chromatid exchanges (SCEs), unscheduled DNA synthesis, and chromosome aberrations. Previous work has shown that SCE induction by Na2SeO3 depends on the presence of red blood cells (RBCs). Therefore, Na2SeO3 uptake and release by RBCs was studied in the present report as was the effect of plasma protein-bound selenium, the end product of Na2SeO3 metabolism by RBCs, on the SCE frequency of purified lymphocyte cultures. Na2SeO3 uptake by human whole blood, RBCs in plasma, RBCs in fetal calf serum, and RBCs in Hanks' balanced salt solution occurs rapidly, reaching a maximum after 2 min (37 degrees C). Release of Na2SeO3 from RBCs depends on the presence of plasma proteins to which the metabolized selenium becomes bound. In spite of the fact that plasma protein-bound selenium is the major product of Na2SeO3 metabolism by RBCs, the SCE frequency of purified lymphocyte cultures was unchanged when plasma protein-bound selenium (7.90 X 10(-6) and 1.19 X 10(-5) M) was added to the medium for the final 19 h of incubation. Further study showed that Na2SeO3 could induce SCEs in blood cultures that had been washed to remove plasma proteins and incubated in medium 199, a maintenance medium lacking fetal calf serum. These findings indicate that a Na2SeO3 metabolite other than plasma protein-bound selenium is responsible for Na2SeO3's SCE-inducing ability in human whole-blood cultures." @default.
- W1530727937 created "2016-06-24" @default.
- W1530727937 creator A5042254915 @default.
- W1530727937 creator A5063994620 @default.
- W1530727937 date "1982-10-01" @default.
- W1530727937 modified "2023-09-24" @default.
- W1530727937 title "Sister-chromatid exchange induction by sodium selenite" @default.
- W1530727937 cites W1543455437 @default.
- W1530727937 cites W1853144955 @default.
- W1530727937 cites W1966203161 @default.
- W1530727937 cites W1966685713 @default.
- W1530727937 cites W1967868943 @default.
- W1530727937 cites W1967961702 @default.
- W1530727937 cites W1968172282 @default.
- W1530727937 cites W1969776684 @default.
- W1530727937 cites W1970904579 @default.
- W1530727937 cites W1984988071 @default.
- W1530727937 cites W1990521725 @default.
- W1530727937 cites W1994631408 @default.
- W1530727937 cites W1998975047 @default.
- W1530727937 cites W2002366675 @default.
- W1530727937 cites W2012582732 @default.
- W1530727937 cites W2017115334 @default.
- W1530727937 cites W2017732997 @default.
- W1530727937 cites W2022714452 @default.
- W1530727937 cites W2022899991 @default.
- W1530727937 cites W2026299695 @default.
- W1530727937 cites W2028981778 @default.
- W1530727937 cites W2041655473 @default.
- W1530727937 cites W2045826085 @default.
- W1530727937 cites W2049085376 @default.
- W1530727937 cites W2062185639 @default.
- W1530727937 cites W2074054925 @default.
- W1530727937 cites W2084465702 @default.
- W1530727937 cites W2088959079 @default.
- W1530727937 cites W2093219151 @default.
- W1530727937 cites W2160597038 @default.
- W1530727937 cites W2277196563 @default.
- W1530727937 doi "https://doi.org/10.1016/0165-1218(82)90138-0" @default.
- W1530727937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7144784" @default.
- W1530727937 hasPublicationYear "1982" @default.
- W1530727937 type Work @default.
- W1530727937 sameAs 1530727937 @default.
- W1530727937 citedByCount "16" @default.
- W1530727937 countsByYear W15307279372012 @default.
- W1530727937 crossrefType "journal-article" @default.
- W1530727937 hasAuthorship W1530727937A5042254915 @default.
- W1530727937 hasAuthorship W1530727937A5063994620 @default.
- W1530727937 hasConcept C146543888 @default.
- W1530727937 hasConcept C153911025 @default.
- W1530727937 hasConcept C178790620 @default.
- W1530727937 hasConcept C185592680 @default.
- W1530727937 hasConcept C203014093 @default.
- W1530727937 hasConcept C25642318 @default.
- W1530727937 hasConcept C2777477808 @default.
- W1530727937 hasConcept C2777761686 @default.
- W1530727937 hasConcept C2779071816 @default.
- W1530727937 hasConcept C552990157 @default.
- W1530727937 hasConcept C553756173 @default.
- W1530727937 hasConcept C55493867 @default.
- W1530727937 hasConcept C62231903 @default.
- W1530727937 hasConcept C86803240 @default.
- W1530727937 hasConceptScore W1530727937C146543888 @default.
- W1530727937 hasConceptScore W1530727937C153911025 @default.
- W1530727937 hasConceptScore W1530727937C178790620 @default.
- W1530727937 hasConceptScore W1530727937C185592680 @default.
- W1530727937 hasConceptScore W1530727937C203014093 @default.
- W1530727937 hasConceptScore W1530727937C25642318 @default.
- W1530727937 hasConceptScore W1530727937C2777477808 @default.
- W1530727937 hasConceptScore W1530727937C2777761686 @default.
- W1530727937 hasConceptScore W1530727937C2779071816 @default.
- W1530727937 hasConceptScore W1530727937C552990157 @default.
- W1530727937 hasConceptScore W1530727937C553756173 @default.
- W1530727937 hasConceptScore W1530727937C55493867 @default.
- W1530727937 hasConceptScore W1530727937C62231903 @default.
- W1530727937 hasConceptScore W1530727937C86803240 @default.
- W1530727937 hasIssue "3" @default.
- W1530727937 hasLocation W15307279371 @default.
- W1530727937 hasLocation W15307279372 @default.
- W1530727937 hasOpenAccess W1530727937 @default.
- W1530727937 hasPrimaryLocation W15307279371 @default.
- W1530727937 hasRelatedWork W1976473001 @default.
- W1530727937 hasRelatedWork W1982159487 @default.
- W1530727937 hasRelatedWork W2031946494 @default.
- W1530727937 hasRelatedWork W2032647638 @default.
- W1530727937 hasRelatedWork W2083714634 @default.
- W1530727937 hasRelatedWork W2095211974 @default.
- W1530727937 hasRelatedWork W2136275918 @default.
- W1530727937 hasRelatedWork W2389268164 @default.
- W1530727937 hasRelatedWork W2409460103 @default.
- W1530727937 hasRelatedWork W3173417825 @default.
- W1530727937 hasVolume "102" @default.
- W1530727937 isParatext "false" @default.
- W1530727937 isRetracted "false" @default.
- W1530727937 magId "1530727937" @default.
- W1530727937 workType "article" @default.