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• W1530879162 abstract "To the Editor: Human longevity is considered to have a significant heritable component.1 Several papers have examined the presence or absence of sex-linked inheritance between parents and children and between twins in population studies,2-4 but conclusive consistent results have not been obtained.5 We examined the presence or absence of sex-linked inheritance of longevity between Japanese centenarians and their relatives. Paternal or maternal lifespans were no different between male and female centenarians. Brothers' and sisters' lifespans also did not differ. The absence of any sex-linked inheritance of longevity was suggested in parent-child relations as well as between siblings. Of the 3,070 centenarians alive at the time of the National Centenarian Survey of Japan (March and May 1993), 2,851 (92.9%; 548 men, 2,303 women) responded. Public health nurses visited and interviewed the centenarians or their families regarding their physical condition and the lifespans of their parents and siblings. Because we could not collect precise data on their parents' date of birth, we assumed that both parents were born in the same year; a cohort was then constructed based on the self-reported lifespans. The same methods were applied for siblings. To exclude the effect of early death mainly from infectious disease, only parents (1,727 fathers, 1,875 mothers) or siblings (3,104 brothers, 3,320 sisters) who survived to age 60 have been compared in the present study of the four sex linkages between parents and centenarians and between centenarians and siblings. There was no significant difference between the sexes in either mean age±standard deviation or age distribution of the centenarians (men aged 101.4±1.4, women aged 101.5±1.6). Kaplan-Meier survival curves demonstrated no significant difference between male and female centenarians in paternal or maternal longevity (Figure 1). Nor was there any significant difference between male and female centenarians with respect to their siblings' lifespans. These findings were consistent when survivors up to age 40 were examined. On the contrary, a significant difference was observed between lifespans of fathers or mothers, or brothers and sisters. Survival analysis was performed using the Kaplan-Meier curves for four cases of sex linkage between centenarians and their parents (male/female centenarian by male/female parents) and for that between centenarians and their siblings. A comparison of the curves was conducted using log-rank test. Our study has two advantages for the examination of inheritance of longevity. First, because the genetic component plays a larger role in living to an exceptional old age,1 the presence or absence of a sex-linked inheritance would become clearer if the relatives of centenarians were also included. Second, in previous studies, the lifespans of both parent and child or those of twins were variables, making for complex analysis.2, 3 In the present study, we reduced the two variables to one by examining the lifespans of parents or siblings between male and female centenarians. The present results for Japanese centenarians clearly demonstrated that neither lifespans of fathers and mothers nor of brothers or sisters differed by sex. The evident findings suggesting no sex-linked inheritance of longevity would be interesting from the viewpoint of human aging and important as basic information for physicians involved in the care of older subjects." @default.
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• W1530879162 date "2004-05-01" @default.
• W1530879162 modified "2023-10-18" @default.
• W1530879162 title "No Sex-Linked Inheritance of Longevity between Japanese Centenarians and Their Relatives" @default.
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• W1530879162 cites W2009285220 @default.
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• W1530879162 doi "https://doi.org/10.1111/j.1532-5415.2004.52230_8.x" @default.
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