Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530929183> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1530929183 abstract "Methylglyoxal (MG) is one of uremic toxins produced by glycolysis that may results in diabetic nephropathy. In this study, we investigated the effect and mechanism of MG on apoptosis in podocytes. Conditionally immortalized podocytes for differentiation were induced by culturing the cells at 37°C for 13~15 days and treated MG with various concentration (0, 50,100, 200, 400 μM). Our data show that MG induced a decrease in cell viability in a dose-dependent manner and increased formation of dichlorofluorescein (DCF)-sensitive intracellular reactive oxygen species (ROS). This enhanced ROS formation was significantly reduced by NADPH oxidase inhibitor (DPI, 5 μM). Furthermore, MG treatment induced apoptosis in podocyte and NADPH oxidase inhibitor inhibited MG-induced podocytes apoptosis via cleavage inhibition of poly (ADP-ribose) polymerase (PARP). MG treatment also induced phosphorylation of extracellular-regulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinases (MAPKs), protein kinase C-alpha and - delta/zeta, and phosphoinositide-3 kinase (PI3K). Pretreatment with these inhibitors inhibited MG-induced phosphorylation of these molecules in podocytes. These results suggest that MG-induced apoptosis may be mediated by signaling of ERK, MAPK, PKC and PI3K in podocyte. Grant Funding Source: KIOM13040" @default.
- W1530929183 created "2016-06-24" @default.
- W1530929183 creator A5004223637 @default.
- W1530929183 creator A5012804401 @default.
- W1530929183 creator A5070548432 @default.
- W1530929183 creator A5079152218 @default.
- W1530929183 creator A5087371439 @default.
- W1530929183 date "2014-04-01" @default.
- W1530929183 modified "2023-10-15" @default.
- W1530929183 title "NADPH oxidase inhibitor inhibits methylglyoxal‐induced podocyte apoptosis (LB729)" @default.
- W1530929183 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb729" @default.
- W1530929183 hasPublicationYear "2014" @default.
- W1530929183 type Work @default.
- W1530929183 sameAs 1530929183 @default.
- W1530929183 citedByCount "0" @default.
- W1530929183 crossrefType "journal-article" @default.
- W1530929183 hasAuthorship W1530929183A5004223637 @default.
- W1530929183 hasAuthorship W1530929183A5012804401 @default.
- W1530929183 hasAuthorship W1530929183A5070548432 @default.
- W1530929183 hasAuthorship W1530929183A5079152218 @default.
- W1530929183 hasAuthorship W1530929183A5087371439 @default.
- W1530929183 hasConcept C126322002 @default.
- W1530929183 hasConcept C181199279 @default.
- W1530929183 hasConcept C185592680 @default.
- W1530929183 hasConcept C190283241 @default.
- W1530929183 hasConcept C2777146197 @default.
- W1530929183 hasConcept C2778592357 @default.
- W1530929183 hasConcept C2779561371 @default.
- W1530929183 hasConcept C2779719074 @default.
- W1530929183 hasConcept C2779765511 @default.
- W1530929183 hasConcept C2780091579 @default.
- W1530929183 hasConcept C55493867 @default.
- W1530929183 hasConcept C71924100 @default.
- W1530929183 hasConcept C86803240 @default.
- W1530929183 hasConcept C95444343 @default.
- W1530929183 hasConceptScore W1530929183C126322002 @default.
- W1530929183 hasConceptScore W1530929183C181199279 @default.
- W1530929183 hasConceptScore W1530929183C185592680 @default.
- W1530929183 hasConceptScore W1530929183C190283241 @default.
- W1530929183 hasConceptScore W1530929183C2777146197 @default.
- W1530929183 hasConceptScore W1530929183C2778592357 @default.
- W1530929183 hasConceptScore W1530929183C2779561371 @default.
- W1530929183 hasConceptScore W1530929183C2779719074 @default.
- W1530929183 hasConceptScore W1530929183C2779765511 @default.
- W1530929183 hasConceptScore W1530929183C2780091579 @default.
- W1530929183 hasConceptScore W1530929183C55493867 @default.
- W1530929183 hasConceptScore W1530929183C71924100 @default.
- W1530929183 hasConceptScore W1530929183C86803240 @default.
- W1530929183 hasConceptScore W1530929183C95444343 @default.
- W1530929183 hasIssue "S1" @default.
- W1530929183 hasLocation W15309291831 @default.
- W1530929183 hasOpenAccess W1530929183 @default.
- W1530929183 hasPrimaryLocation W15309291831 @default.
- W1530929183 hasRelatedWork W1993196397 @default.
- W1530929183 hasRelatedWork W2025302870 @default.
- W1530929183 hasRelatedWork W2036801917 @default.
- W1530929183 hasRelatedWork W2038104990 @default.
- W1530929183 hasRelatedWork W2045373863 @default.
- W1530929183 hasRelatedWork W2068820225 @default.
- W1530929183 hasRelatedWork W2070177458 @default.
- W1530929183 hasRelatedWork W2082007973 @default.
- W1530929183 hasRelatedWork W2112756559 @default.
- W1530929183 hasRelatedWork W2130550927 @default.
- W1530929183 hasRelatedWork W2274086937 @default.
- W1530929183 hasRelatedWork W2278408231 @default.
- W1530929183 hasRelatedWork W2323946663 @default.
- W1530929183 hasRelatedWork W2361899839 @default.
- W1530929183 hasRelatedWork W2375132741 @default.
- W1530929183 hasRelatedWork W2569651681 @default.
- W1530929183 hasRelatedWork W2739609379 @default.
- W1530929183 hasRelatedWork W2776029970 @default.
- W1530929183 hasRelatedWork W3126854217 @default.
- W1530929183 hasRelatedWork W77353407 @default.
- W1530929183 hasVolume "28" @default.
- W1530929183 isParatext "false" @default.
- W1530929183 isRetracted "false" @default.
- W1530929183 magId "1530929183" @default.
- W1530929183 workType "article" @default.