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• W1530947319 abstract "Schistosomiasis is one of the world’s most widely distributed and prevalent parasitic diseases, with approximately 700 million people at risk of infection. The vast majority of human cases of the disease are found in Africa, with distribution in virtually all corners of the continent, bar the Sahara and Namib deserts and the depths of the Congo jungle (Hotez et al., 2009). Preprubescent children, and particularly boys, are the age group most at risk from adverse clinical symptoms and are frequently targeted for treatment interventions, yet even with readily available drugs (namely praziquantel), the pervasiveness of the intermediate host snails and the ease at which re-infection occurs has hampered attempts to manage the disease in many places (Standley et al., 2009, Fenwick, 2009). Less widely recognized is that some species of Schistosoma, including several which commonly affect man, can also be infective in other mammalian species, and particularly in non-human primates. Given current high levels of research interest into emerging zoonotic diseases, the status of schistosomiasis as a zoonotic infection is in need of re-appraisal, especially in light of advances in application of molecular epidemiological methods; it has been 20 years since the last formal review was published (Ouma and Fenwick, 1991), with earlier appraisals fully half a century ago (Nelson, 1960, Nelson et al., 1962). By comparing historical accounts to on-going, cutting edge research using molecular tools, it will be possible to gain an insight into the dynamics of schistosomiasis in human and other hosts and whether this relationship is changing as a result of anthropogenic activities. As such, this chapter provides an overview of zoonoses involving schistosomiasis, focusing on Africa where the burden of the disease is highest, and also discusses the ways in which this information can be integrated into more effective conservation management and human disease control strategies. The emphasis will be on the most common forms of human schistosomiasis and how animals not only may suffer clinical manifestations from infection, but may also act as reservoirs for schistosomiasis, thus confounding control efforts that focus mainly on the treatment of humans." @default.
• W1530947319 created "2016-06-24" @default.
• W1530947319 creator A5022633993 @default.
• W1530947319 creator A5079757569 @default.
• W1530947319 creator A5091288155 @default.
• W1530947319 date "2012-01-13" @default.
• W1530947319 modified "2023-10-14" @default.
• W1530947319 title "Out of Animals and Back Again: Schistosomiasis as a Zoonosis in Africa" @default.
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