FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1530963485> ?p ?o ?g. }

• W1530963485 endingPage "874" @default.
• W1530963485 startingPage "863" @default.
• W1530963485 abstract "Induction of apoptosis plays a crucial role in the response of tumors to treatment. Thus, we investigated the pharmacodynamics and tumor saturation kinetics of a death receptor 5 antibody (anti-DR5) when combined with chemotherapeutics. For our investigations, we applied an imaging method that allows monitoring of apoptosis noninvasively in living mice. A stably transfected apoptosis reporter based on split luciferase technology facilitates to screen various chemotherapeutics and anti-DR5 on their ability to induce apoptosis in glioblastoma cells in vitro as well as in vivo. We found that doxorubicin (DOX) treatment in vitro led to significant apoptosis induction within 48 hours and to a 2.3-fold increased anti-DR5 binding to the cell surface. In contrast, cisplatin and 5-fluorouracil (5-FU) treatment altered anti-DR5 binding only marginally. Induction of apoptosis by treatment with anti-DR5 was dose- and time-dependent (both in vitro and in vivo). Simultaneous visualization of fluorescence-labeled anti-DR5 in tumor tissue and apoptosis revealed maximal apoptosis induction immediately after the compound had reached tumor site. Regarding combination therapy of anti-DR5 and DOX, we found that the sequential application of DOX before anti-DR5 resulted in synergistically enhanced apoptosis reporter activity. In striking contrast, anti-DR5 given before DOX did not lead to increased apoptosis induction. We suggest that DOX-induced recruitment of DR5 to the cell surface impacts the enhanced apoptotic effect that can be longitudinally monitored by apoptosis imaging. This study demonstrates that the combination of apoptosis and fluorescence imaging is an excellent method for optimizing dosing and treatment schedules in preclinical cancer models." @default.
• W1530963485 created "2016-06-24" @default.
• W1530963485 creator A5000162479 @default.
• W1530963485 creator A5007101278 @default.
• W1530963485 creator A5066264229 @default.
• W1530963485 creator A5073502196 @default.
• W1530963485 creator A5085476171 @default.
• W1530963485 date "2013-08-01" @default.
• W1530963485 modified "2023-10-15" @default.
• W1530963485 title "Noninvasive Monitoring of Pharmacodynamics and Kinetics of a Death Receptor 5 Antibody and Its Enhanced Apoptosis Induction in Sequential Application with Doxorubicin" @default.
• W1530963485 cites W1551829042 @default.
• W1530963485 cites W1674551699 @default.
• W1530963485 cites W1967928952 @default.
• W1530963485 cites W1972083405 @default.
• W1530963485 cites W1978813721 @default.
• W1530963485 cites W1998422493 @default.
• W1530963485 cites W2003729662 @default.
• W1530963485 cites W2005131665 @default.
• W1530963485 cites W2009183786 @default.
• W1530963485 cites W2012410102 @default.
• W1530963485 cites W2016825334 @default.
• W1530963485 cites W2020812892 @default.
• W1530963485 cites W2020967120 @default.
• W1530963485 cites W2034269086 @default.
• W1530963485 cites W2037805669 @default.
• W1530963485 cites W2038301672 @default.
• W1530963485 cites W2047957855 @default.
• W1530963485 cites W2053058618 @default.
• W1530963485 cites W2057428268 @default.
• W1530963485 cites W2059912335 @default.
• W1530963485 cites W2068711271 @default.
• W1530963485 cites W2074106785 @default.
• W1530963485 cites W2074326191 @default.
• W1530963485 cites W2085485449 @default.
• W1530963485 cites W2094570524 @default.
• W1530963485 cites W2096186936 @default.
• W1530963485 cites W2102630679 @default.
• W1530963485 cites W2106765129 @default.
• W1530963485 cites W2111034566 @default.
• W1530963485 cites W2113361289 @default.
• W1530963485 cites W2114714381 @default.
• W1530963485 cites W2116281754 @default.
• W1530963485 cites W2123183032 @default.
• W1530963485 cites W2150636063 @default.
• W1530963485 cites W2154120853 @default.
• W1530963485 cites W2156257249 @default.
• W1530963485 doi "https://doi.org/10.1593/neo.13932" @default.
• W1530963485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3730039" @default.
• W1530963485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23908588" @default.
• W1530963485 hasPublicationYear "2013" @default.
• W1530963485 type Work @default.
• W1530963485 sameAs 1530963485 @default.
• W1530963485 citedByCount "13" @default.
• W1530963485 countsByYear W15309634852013 @default.
• W1530963485 countsByYear W15309634852014 @default.
• W1530963485 countsByYear W15309634852015 @default.
• W1530963485 countsByYear W15309634852016 @default.
• W1530963485 countsByYear W15309634852023 @default.
• W1530963485 crossrefType "journal-article" @default.
• W1530963485 hasAuthorship W1530963485A5000162479 @default.
• W1530963485 hasAuthorship W1530963485A5007101278 @default.
• W1530963485 hasAuthorship W1530963485A5066264229 @default.
• W1530963485 hasAuthorship W1530963485A5073502196 @default.
• W1530963485 hasAuthorship W1530963485A5085476171 @default.
• W1530963485 hasBestOaLocation W15309634851 @default.
• W1530963485 hasConcept C126322002 @default.
• W1530963485 hasConcept C150903083 @default.
• W1530963485 hasConcept C190283241 @default.
• W1530963485 hasConcept C202751555 @default.
• W1530963485 hasConcept C207001950 @default.
• W1530963485 hasConcept C2776694085 @default.
• W1530963485 hasConcept C2778239845 @default.
• W1530963485 hasConcept C2781303535 @default.
• W1530963485 hasConcept C31573885 @default.
• W1530963485 hasConcept C502942594 @default.
• W1530963485 hasConcept C55493867 @default.
• W1530963485 hasConcept C71924100 @default.
• W1530963485 hasConcept C86803240 @default.
• W1530963485 hasConcept C95444343 @default.
• W1530963485 hasConcept C98274493 @default.
• W1530963485 hasConceptScore W1530963485C126322002 @default.
• W1530963485 hasConceptScore W1530963485C150903083 @default.
• W1530963485 hasConceptScore W1530963485C190283241 @default.
• W1530963485 hasConceptScore W1530963485C202751555 @default.
• W1530963485 hasConceptScore W1530963485C207001950 @default.
• W1530963485 hasConceptScore W1530963485C2776694085 @default.
• W1530963485 hasConceptScore W1530963485C2778239845 @default.
• W1530963485 hasConceptScore W1530963485C2781303535 @default.
• W1530963485 hasConceptScore W1530963485C31573885 @default.
• W1530963485 hasConceptScore W1530963485C502942594 @default.
• W1530963485 hasConceptScore W1530963485C55493867 @default.
• W1530963485 hasConceptScore W1530963485C71924100 @default.
• W1530963485 hasConceptScore W1530963485C86803240 @default.
• W1530963485 hasConceptScore W1530963485C95444343 @default.
• W1530963485 hasConceptScore W1530963485C98274493 @default.
• W1530963485 hasIssue "8" @default.
• W1530963485 hasLocation W15309634851 @default.
• W1530963485 hasLocation W15309634852 @default.

• next