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• W1531026064 abstract "Abstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine protein kinase that functions as a central regulator of cellular growth and metabolism by forming two distinct complexes: TOR complex 1 (TORC1) and TORC2. As well as TORC1, TORC2 plays a key role in regulation of cell growth. But little is known about how TORC2 regulates cell growth. The transcription factor Myc also plays a critical role in cell proliferation and growth. Here we report that TORC2 and Myc regulate cell growth via a common pathway. Expression of Myc fully rescued growth defects associated with lst8 and rictor mutations, both of which encode essential components of TORC2. Furthermore, loss of TORC2 disrupted the nuclear localization of Myc and inhibited Myc-dependent transcription. Together, our results reveal a Myc-dependent pathway by which TORC2 regulates cell growth." @default.
• W1531026064 created "2016-06-24" @default.
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• W1531026064 date "2015-05-22" @default.
• W1531026064 modified "2023-10-18" @default.
• W1531026064 title "Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila" @default.
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• W1531026064 doi "https://doi.org/10.1038/srep10339" @default.
• W1531026064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4441130" @default.
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