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• W1531144136 abstract "Research Article1 September 1990free access Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. C. A. Dionne C. A. Dionne Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author G. Crumley G. Crumley Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author F. Bellot F. Bellot Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author J. M. Kaplow J. M. Kaplow Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author G. Searfoss G. Searfoss Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author M. Ruta M. Ruta Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author W. H. Burgess W. H. Burgess Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author M. Jaye M. Jaye Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author J. Schlessinger J. Schlessinger Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author C. A. Dionne C. A. Dionne Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author G. Crumley G. Crumley Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author F. Bellot F. Bellot Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author J. M. Kaplow J. M. Kaplow Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author G. Searfoss G. Searfoss Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author M. Ruta M. Ruta Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author W. H. Burgess W. H. Burgess Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author M. Jaye M. Jaye Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author J. Schlessinger J. Schlessinger Rorer Central Research, King of Prussia, PA 19406. Search for more papers by this author Author Information C. A. Dionne1, G. Crumley1, F. Bellot1, J. M. Kaplow1, G. Searfoss1, M. Ruta1, W. H. Burgess1, M. Jaye1 and J. Schlessinger1 1Rorer Central Research, King of Prussia, PA 19406. The EMBO Journal (1990)9:2685-2692https://doi.org/10.1002/j.1460-2075.1990.tb07454.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The fibroblast growth factor (FGF) family consists of at least seven closely related polypeptide mitogens which exert their activities by binding and activation of specific cell surface receptors. Unanswered questions have been whether there are multiple FGF receptors and what factors determine binding specificity and biological response. We report the complete cDNA cloning of two human genes previously designated flg and bek. These genes encode two similar but distinct cell surface receptors comprised of an extracellular domain with three immunoglobulin-like regions, a single transmembrane domain, and a cytoplasmic portion containing a tyrosine kinase domain with a typical kinase insert. The expression of these two cDNAs in transfected NIH 3T3 cells led to the biosynthesis of proteins of 150 kd and 135 kd for flg and bek, respectively. Direct binding experiments with radiolabeled acidic FGF (aFGF) or basic FGF (bFGF), inhibition of binding with native growth factors, and Scatchard analysis of the binding data indicated that bek and flg bind either aFGF or bFGF with dissociation constants of (2-15) x 10(-11) M. The high affinity binding of two distinct growth factors to each of two different receptors represents a unique double redundancy without precedence among polypeptide growth factor-receptor interactions. Previous ArticleNext Article Volume 9Issue 91 September 1990In this issue RelatedDetailsLoading ..." @default.
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• W1531144136 date "1990-09-01" @default.
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• W1531144136 title "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors." @default.
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• W1531144136 doi "https://doi.org/10.1002/j.1460-2075.1990.tb07454.x" @default.
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