FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531150180> ?p ?o ?g. }

• W1531150180 abstract "Extracellular stimuli affecting mechanisms of transcriptional control of the preproenkephalin gene link stimulus-secretion-synthesis coupling to transmitter phenotypic expression. In order to define distal and proximal genomic regions that might participate in transcriptionally active protein-DNA interactions, DNaseI hypersensitivity assays were conducted. Four DNaseI-hypersensitive regions were identified at -3000, -2500, -1800, and -200 base pairs (bp) relative to the somatic start site. The appearance of a site over the proximal promoter/enhancer region (-200 bp) is of interest since we and others have published a detailed footprint and functional analysis of this region using rat tissues. While liver (which does not express proenkephalin mRNA) displays essentially no hypersensitivity here, adrenal gland preparations show a strong signal and striatal tissue a significantly weaker signal. Cholinergic induction of proenkephalin mRNA was not associated with a change in hypersensitivity pattern. These data suggest that chromatin structure may have an influence on preproenkephalin transcriptional control and that cholinergic-inducible cis-acting DNA elements may reside within subdomains of at least these four hypersensitivity sites. Understanding the basis of this open chromatin structure should aid in identifying genomic mechanisms involved in tissue-specific expression and suggest avenues of future study." @default.
• W1531150180 created "2016-06-24" @default.
• W1531150180 creator A5013592135 @default.
• W1531150180 creator A5033416097 @default.
• W1531150180 date "1992-10-01" @default.
• W1531150180 modified "2023-09-30" @default.
• W1531150180 title "Tissue-specific DNaseI hypersensitivity regions are located in the 5'-region of the rat preproenkephalin gene." @default.
• W1531150180 cites W149877699 @default.
• W1531150180 cites W1501459115 @default.
• W1531150180 cites W1563989680 @default.
• W1531150180 cites W1573850071 @default.
• W1531150180 cites W1869906673 @default.
• W1531150180 cites W1889572575 @default.
• W1531150180 cites W1943482784 @default.
• W1531150180 cites W1964064195 @default.
• W1531150180 cites W1976989696 @default.
• W1531150180 cites W1978172569 @default.
• W1531150180 cites W1986708473 @default.
• W1531150180 cites W1988568219 @default.
• W1531150180 cites W1996409695 @default.
• W1531150180 cites W2012454894 @default.
• W1531150180 cites W2012749100 @default.
• W1531150180 cites W2017883686 @default.
• W1531150180 cites W2033410250 @default.
• W1531150180 cites W2036223295 @default.
• W1531150180 cites W2053995748 @default.
• W1531150180 cites W2059559415 @default.
• W1531150180 cites W2060165845 @default.
• W1531150180 cites W2063248559 @default.
• W1531150180 cites W2066089226 @default.
• W1531150180 cites W2067544735 @default.
• W1531150180 cites W2067746047 @default.
• W1531150180 cites W2069002774 @default.
• W1531150180 cites W2071632892 @default.
• W1531150180 cites W2071785245 @default.
• W1531150180 cites W2072358867 @default.
• W1531150180 cites W2072393635 @default.
• W1531150180 cites W2073350856 @default.
• W1531150180 cites W2081028995 @default.
• W1531150180 cites W2088259380 @default.
• W1531150180 cites W2088297297 @default.
• W1531150180 cites W2092676628 @default.
• W1531150180 cites W2092819969 @default.
• W1531150180 cites W2098517630 @default.
• W1531150180 cites W2098553579 @default.
• W1531150180 cites W2099677521 @default.
• W1531150180 cites W2115736681 @default.
• W1531150180 cites W2134939519 @default.
• W1531150180 cites W2169741685 @default.
• W1531150180 cites W2177510297 @default.
• W1531150180 cites W2233662905 @default.
• W1531150180 cites W2280111083 @default.
• W1531150180 cites W2416022039 @default.
• W1531150180 doi "https://doi.org/10.1016/s0021-9258(19)88627-1" @default.
• W1531150180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1400296" @default.
• W1531150180 hasPublicationYear "1992" @default.
• W1531150180 type Work @default.
• W1531150180 sameAs 1531150180 @default.
• W1531150180 citedByCount "3" @default.
• W1531150180 crossrefType "journal-article" @default.
• W1531150180 hasAuthorship W1531150180A5013592135 @default.
• W1531150180 hasAuthorship W1531150180A5033416097 @default.
• W1531150180 hasBestOaLocation W15311501801 @default.
• W1531150180 hasConcept C104317684 @default.
• W1531150180 hasConcept C111936080 @default.
• W1531150180 hasConcept C150194340 @default.
• W1531150180 hasConcept C153911025 @default.
• W1531150180 hasConcept C165864922 @default.
• W1531150180 hasConcept C169760540 @default.
• W1531150180 hasConcept C170493617 @default.
• W1531150180 hasConcept C22885893 @default.
• W1531150180 hasConcept C2777515746 @default.
• W1531150180 hasConcept C2777803847 @default.
• W1531150180 hasConcept C2781063702 @default.
• W1531150180 hasConcept C54355233 @default.
• W1531150180 hasConcept C58237431 @default.
• W1531150180 hasConcept C83640560 @default.
• W1531150180 hasConcept C86803240 @default.
• W1531150180 hasConcept C95444343 @default.
• W1531150180 hasConceptScore W1531150180C104317684 @default.
• W1531150180 hasConceptScore W1531150180C111936080 @default.
• W1531150180 hasConceptScore W1531150180C150194340 @default.
• W1531150180 hasConceptScore W1531150180C153911025 @default.
• W1531150180 hasConceptScore W1531150180C165864922 @default.
• W1531150180 hasConceptScore W1531150180C169760540 @default.
• W1531150180 hasConceptScore W1531150180C170493617 @default.
• W1531150180 hasConceptScore W1531150180C22885893 @default.
• W1531150180 hasConceptScore W1531150180C2777515746 @default.
• W1531150180 hasConceptScore W1531150180C2777803847 @default.
• W1531150180 hasConceptScore W1531150180C2781063702 @default.
• W1531150180 hasConceptScore W1531150180C54355233 @default.
• W1531150180 hasConceptScore W1531150180C58237431 @default.
• W1531150180 hasConceptScore W1531150180C83640560 @default.
• W1531150180 hasConceptScore W1531150180C86803240 @default.
• W1531150180 hasConceptScore W1531150180C95444343 @default.
• W1531150180 hasLocation W15311501801 @default.
• W1531150180 hasOpenAccess W1531150180 @default.
• W1531150180 hasPrimaryLocation W15311501801 @default.
• W1531150180 hasRelatedWork W141803538 @default.
• W1531150180 hasRelatedWork W1507867989 @default.

• next