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• W1531165741 abstract "Microbubble ultrasound contrast agents allow imaging of the vasculature with excellent resolution and signal‐to‐noise ratios. Contrast in microbubbles derives from their interaction with an ultrasound wave to generate signal at harmonic frequencies of the stimulating pulse; subtracting the elastic echo caused by the surrounding tissue can enhance the specificity of these harmonic signals significantly. The nonlinear acoustic emission is caused by pressure‐driven microbubble size fluctuations, which in both theoretical descriptions and empirical measurements was found to depend on the mechanical properties of the shell that encapsulates the microbubble as well as stabilizes it against the surrounding aqueous environment. Thus biochemically induced switching between a rigid ‘off’ state and a flexible ‘on’ state provides a mechanism for sensing chemical markers for disease. In our research, we coupled DNA oligonucleotides to a stabilizing lipid monolayer to modulate stiffness of the shell and thereby induce stimulus–responsive behavior. In initial proof‐of‐principle studies, it was found that signal modulation came primarily from DNA crosslinks preventing the microbubble size oscillations rather than merely damping the signal. Next, these microbubbles were redesigned to include an aptamer sequence in the crosslinking strand, which not only allowed the sensing of the clotting enzyme thrombin but also provided a general strategy for sensing other soluble biomarkers in the bloodstream. Finally, the thrombin‐sensitive microbubbles were validated in a rabbit model, presenting the first example of an ultrasound contrast agent that could differentiate between active and inactive clots for the diagnosis of deep venous thrombosis. WIREs Nanomed Nanobiotechnol 2015, 7:111–123. doi: 10.1002/wnan.1285 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures" @default.
• W1531165741 created "2016-06-24" @default.
• W1531165741 creator A5029443306 @default.
• W1531165741 creator A5030191726 @default.
• W1531165741 creator A5073481717 @default.
• W1531165741 date "2014-09-06" @default.
• W1531165741 modified "2023-10-08" @default.
• W1531165741 title "Stimulus-responsive ultrasound contrast agents for clinical imaging: motivations, demonstrations, and future directions" @default.
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• W1531165741 doi "https://doi.org/10.1002/wnan.1285" @default.
• W1531165741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4268373" @default.
• W1531165741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25195785" @default.
• W1531165741 hasPublicationYear "2014" @default.
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