FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531167536> ?p ?o ?g. }

• W1531167536 abstract "Expression of an amylase/CAT hybrid gene was analyzed in transgenic mice. The amylase promoter was derived from a pancreatic amylase gene whose expression is repressed in diabetic animals. Pancreas-specific expression of the amylase/chloramphenicol acetyl-transferase (CAT) construct was observed in two independent transgenic lines. Correct initiation of transcription was demonstrated by protection of an anti-sense riboprobe. To evaluate the insulin dependence of the hybrid gene, diabetes was induced by treatment with streptozotocin. As a result of this treatment, pancreatic CAT activity was reduced to undetectable levels. Subsequent administration of insulin restored CAT activity to normal levels. The abundance of CAT transcripts was also greatly reduced in diabetic pancreas. These studies localize the determinants of pancreas specificity and insulin dependence to the region between -208 and +19 of the mouse pancreatic Amy-2.2 gene. The results are consistent with an effect of insulin on amylase transcription, rather than post-transcriptional regulation of mRNA processing or stability." @default.
• W1531167536 created "2016-06-24" @default.
• W1531167536 creator A5019319452 @default.
• W1531167536 creator A5041931702 @default.
• W1531167536 creator A5045750343 @default.
• W1531167536 creator A5070868538 @default.
• W1531167536 creator A5088331199 @default.
• W1531167536 date "1988-11-01" @default.
• W1531167536 modified "2023-10-01" @default.
• W1531167536 title "Insulin response of a hybrid amylase/CAT gene in transgenic mice." @default.
• W1531167536 cites W1492123165 @default.
• W1531167536 cites W1563828822 @default.
• W1531167536 cites W1564906738 @default.
• W1531167536 cites W1603838026 @default.
• W1531167536 cites W1630286573 @default.
• W1531167536 cites W1653320450 @default.
• W1531167536 cites W1783500979 @default.
• W1531167536 cites W1861378058 @default.
• W1531167536 cites W1946050661 @default.
• W1531167536 cites W1954580706 @default.
• W1531167536 cites W2019841328 @default.
• W1531167536 cites W2033037565 @default.
• W1531167536 cites W2061236267 @default.
• W1531167536 cites W2078119356 @default.
• W1531167536 cites W2083141726 @default.
• W1531167536 cites W2144206181 @default.
• W1531167536 cites W2150600019 @default.
• W1531167536 cites W2159282095 @default.
• W1531167536 doi "https://doi.org/10.1016/s0021-9258(18)37419-2" @default.
• W1531167536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2460451" @default.
• W1531167536 hasPublicationYear "1988" @default.
• W1531167536 type Work @default.
• W1531167536 sameAs 1531167536 @default.
• W1531167536 citedByCount "36" @default.
• W1531167536 crossrefType "journal-article" @default.
• W1531167536 hasAuthorship W1531167536A5019319452 @default.
• W1531167536 hasAuthorship W1531167536A5041931702 @default.
• W1531167536 hasAuthorship W1531167536A5045750343 @default.
• W1531167536 hasAuthorship W1531167536A5070868538 @default.
• W1531167536 hasAuthorship W1531167536A5088331199 @default.
• W1531167536 hasBestOaLocation W15311675361 @default.
• W1531167536 hasConcept C102230213 @default.
• W1531167536 hasConcept C104317684 @default.
• W1531167536 hasConcept C105580179 @default.
• W1531167536 hasConcept C126322002 @default.
• W1531167536 hasConcept C134018914 @default.
• W1531167536 hasConcept C138885662 @default.
• W1531167536 hasConcept C141035611 @default.
• W1531167536 hasConcept C150194340 @default.
• W1531167536 hasConcept C170835558 @default.
• W1531167536 hasConcept C179926584 @default.
• W1531167536 hasConcept C181199279 @default.
• W1531167536 hasConcept C2778764654 @default.
• W1531167536 hasConcept C2778837531 @default.
• W1531167536 hasConcept C2779280383 @default.
• W1531167536 hasConcept C2779306644 @default.
• W1531167536 hasConcept C41895202 @default.
• W1531167536 hasConcept C55493867 @default.
• W1531167536 hasConcept C555293320 @default.
• W1531167536 hasConcept C71924100 @default.
• W1531167536 hasConcept C81439078 @default.
• W1531167536 hasConcept C86803240 @default.
• W1531167536 hasConceptScore W1531167536C102230213 @default.
• W1531167536 hasConceptScore W1531167536C104317684 @default.
• W1531167536 hasConceptScore W1531167536C105580179 @default.
• W1531167536 hasConceptScore W1531167536C126322002 @default.
• W1531167536 hasConceptScore W1531167536C134018914 @default.
• W1531167536 hasConceptScore W1531167536C138885662 @default.
• W1531167536 hasConceptScore W1531167536C141035611 @default.
• W1531167536 hasConceptScore W1531167536C150194340 @default.
• W1531167536 hasConceptScore W1531167536C170835558 @default.
• W1531167536 hasConceptScore W1531167536C179926584 @default.
• W1531167536 hasConceptScore W1531167536C181199279 @default.
• W1531167536 hasConceptScore W1531167536C2778764654 @default.
• W1531167536 hasConceptScore W1531167536C2778837531 @default.
• W1531167536 hasConceptScore W1531167536C2779280383 @default.
• W1531167536 hasConceptScore W1531167536C2779306644 @default.
• W1531167536 hasConceptScore W1531167536C41895202 @default.
• W1531167536 hasConceptScore W1531167536C55493867 @default.
• W1531167536 hasConceptScore W1531167536C555293320 @default.
• W1531167536 hasConceptScore W1531167536C71924100 @default.
• W1531167536 hasConceptScore W1531167536C81439078 @default.
• W1531167536 hasConceptScore W1531167536C86803240 @default.
• W1531167536 hasLocation W15311675361 @default.
• W1531167536 hasOpenAccess W1531167536 @default.
• W1531167536 hasPrimaryLocation W15311675361 @default.
• W1531167536 hasRelatedWork W1492123165 @default.
• W1531167536 hasRelatedWork W1564906738 @default.
• W1531167536 hasRelatedWork W1581798949 @default.
• W1531167536 hasRelatedWork W1664036759 @default.
• W1531167536 hasRelatedWork W1861378058 @default.
• W1531167536 hasRelatedWork W1946050661 @default.
• W1531167536 hasRelatedWork W1968102722 @default.
• W1531167536 hasRelatedWork W1985296472 @default.
• W1531167536 hasRelatedWork W2032022822 @default.
• W1531167536 hasRelatedWork W2033037565 @default.
• W1531167536 hasRelatedWork W2058331480 @default.
• W1531167536 hasRelatedWork W2059911808 @default.
• W1531167536 hasRelatedWork W2060333964 @default.
• W1531167536 hasRelatedWork W2074060029 @default.

• next