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- W1531194664 abstract "The nucleus is an important target of signal transduction by growth factor receptors that stimulate mitogen-activated protein (MAP) kinases. We tested the hypothesis that MAP kinases have a signaling role within the nucleus by examining the effect of the expression of a human MAP kinase isoform (p41mapk) in tissue culture cells. The expressed p41mapk was found to be localized in both the cytoplasmic and nuclear compartments of the cells. Significantly, the expression of p41mapk caused an increase in the phosphorylation of a nuclear substrate: Ser62 of c-Myc. Phosphorylation at Ser62 stimulated the activity of the NH2-terminal transactivation domain of c-Myc. Thus, p41mapk causes the phosphorylation and regulation of a physiologically significant nuclear target of signal transduction. These data establish that at least one MAP kinase isoform has a nuclear role during signal transduction." @default.
- W1531194664 created "2016-06-24" @default.
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- W1531194664 creator A5080533757 @default.
- W1531194664 creator A5086587331 @default.
- W1531194664 date "1992-12-01" @default.
- W1531194664 modified "2023-10-16" @default.
- W1531194664 title "Signal transduction within the nucleus by mitogen-activated protein kinase." @default.
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- W1531194664 doi "https://doi.org/10.1016/s0021-9258(18)35834-4" @default.
- W1531194664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1332967" @default.
- W1531194664 hasPublicationYear "1992" @default.
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