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- W1531227978 abstract "RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. By taking advantage of the cell's RNAi machinery, small interfering RNA (siRNA) duplexes of 21–25 nt in length can be introduced into cells to induce the specific degradation of targeted mRNAs. With the specificity and high efficacy of RNAi, the prospects of using siRNAs for treating human malignancies and other diseases remain tantalizing, but are still not fully realized due to several key barriers, such as inefficient delivery to the correct cells or tissues; suboptimal gene silencing activity owing to instability and unavailability of the RNAi agents; and systemic toxicity due to off-target effects or innate immune activation. Recent setbacks in RNAi clinical translation have stimulated further investigation into the molecular mechanism of RNAi as well as safe and efficient delivery formulations for achieving clinically relevant post-transcriptional gene silencing in the desired target tissue. In this chapter, we discuss the mechanisms of RNAi and the major barriers in achieving efficient RNAi delivery, particularly emphasizing recent advances addressing these challenges." @default.
- W1531227978 created "2016-06-24" @default.
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- W1531227978 date "2013-04-26" @default.
- W1531227978 modified "2023-10-17" @default.
- W1531227978 title "Environmentally-Responsive Nanogels for siRNA Delivery" @default.
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- W1531227978 doi "https://doi.org/10.1002/9781118610749.ch10" @default.
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