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- W1531229502 abstract "The brain is at the very limit of its energy supply and has evolved specific means of adapting function to energy supply, of which mitochondria form a crucial link. Neurotrophic and inflammatory processes may not only have opposite effects on neuroplasticity, but also involve opposite effects on mitochondrial oxidative phosphorylation and glycolytic processes, respectively, modulated by stress and glucocorticoids, which also have marked effects on mood. Neurodegenerative processes show marked disorders in oxidative metabolism in key brain areas, sometimes decades before symptoms appear ( P arkinson's and A lzheimer's diseases). We argue that brain‐derived neurotrophic factor couples activity to changes in respiratory efficiency and these effects may be opposed by inflammatory cytokines, a key factor in neurodegenerative processes. Linked Articles This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue‐8" @default.
- W1531229502 created "2016-06-24" @default.
- W1531229502 creator A5019760593 @default.
- W1531229502 creator A5027761174 @default.
- W1531229502 creator A5050308649 @default.
- W1531229502 creator A5080135978 @default.
- W1531229502 date "2014-03-28" @default.
- W1531229502 modified "2023-10-01" @default.
- W1531229502 title "Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?" @default.
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