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• W1531283035 startingPage "10338" @default.
• W1531283035 abstract "When acutely dissociated small-diameter dorsal root ganglion (DRG) neurons were stimulated with repeated current injections or prolonged application of capsaicin, their action potential firing quickly adapted. Because TTX-resistant (TTX-R) sodium current in these presumptive nociceptors generates a large fraction of depolarizing current during the action potential, we examined the possible role of inactivation of TTX-R sodium channels in producing adaptation. Under voltage clamp, TTX-R current elicited by short depolarizations showed strong use dependence at frequencies as low as 1 Hz, although recovery from fast inactivation was complete in approximately 10-30 msec. This use-dependent reduction was the result of the entry of TTX-R sodium channels into slow inactivated states. Slow inactivation was more effectively produced by steady depolarization than by cycling channels through open states. Slow inactivation was steeply voltage dependent, with a Boltzmann slope factor of 5 mV, a midpoint near -45 mV (5 sec conditioning pulses), and completeness of approximately 93% positive to -20 mV. The time constant for entry (approximately 200 msec) was independent of voltage from -20 mV to +60 mV, whereas recovery kinetics were moderately voltage dependent (time constant, approximately 1.5 sec at -60 mV and approximately 0.5 sec at -100 mV). Using a prerecorded current-clamp response to capsaicin as a voltage-clamp command waveform, we found that adaptation of firing occurred with a time course similar to that of development of slow inactivation. Thus, slow inactivation of the TTX-R sodium current limits the duration of small DRG cell firing in response to maintained stimuli and may contribute to cross desensitization between chemical and electrical stimuli." @default.
• W1531283035 created "2016-06-24" @default.
• W1531283035 creator A5087690593 @default.
• W1531283035 creator A5089756633 @default.
• W1531283035 date "2003-11-12" @default.
• W1531283035 modified "2023-10-14" @default.
• W1531283035 title "Role of Tetrodotoxin-Resistant Na⁺Current Slow Inactivation in Adaptation of Action Potential Firing in Small-Diameter Dorsal Root Ganglion Neurons" @default.
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• W1531283035 doi "https://doi.org/10.1523/jneurosci.23-32-10338.2003" @default.
• W1531283035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741008" @default.
• W1531283035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14614093" @default.
• W1531283035 hasPublicationYear "2003" @default.
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