Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531401474> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1531401474 endingPage "2876" @default.
- W1531401474 startingPage "2871" @default.
- W1531401474 abstract "Direct gene transfer into muscle can lead to sustained gene expression at the injected sites. Here we tested the ability of in vivo gene transfection to immunize mice against an isolated human IgV region. The Humkv325 germline kappa L chain V gene encodes the kappa L chain in V regions of several human IgM autoantibodies and is used frequently in chronic lymphocytic leukemia. This gene was inserted into a mammalian expression vector, pREP7, to produce pREVk3. Mice injected i.m. with pREVk3 produced antibodies against the V region of Glo, a human monoclonal IgM paraprotein whose kappa L chain is encoded by Humkv325. Co-injection of an expression vector encoding IL-2 enhanced anti-Glo antibody production fivefold and induced a localized delayed hypersensitivity reaction. Antibody production also was induced when vectors encoding Humkv325 and IL-2 were injected s.c. These experiments demonstrate that gene immunization vectors can stimulate immune responses to antibody V region determinants." @default.
- W1531401474 created "2016-06-24" @default.
- W1531401474 creator A5013526431 @default.
- W1531401474 creator A5036828560 @default.
- W1531401474 creator A5077374522 @default.
- W1531401474 creator A5082654587 @default.
- W1531401474 creator A5085501629 @default.
- W1531401474 creator A5086448751 @default.
- W1531401474 creator A5087207909 @default.
- W1531401474 date "1993-09-01" @default.
- W1531401474 modified "2023-10-17" @default.
- W1531401474 title "Induction of antibodies to a kappa V region by gene immunization." @default.
- W1531401474 doi "https://doi.org/10.4049/jimmunol.151.5.2871" @default.
- W1531401474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8360497" @default.
- W1531401474 hasPublicationYear "1993" @default.
- W1531401474 type Work @default.
- W1531401474 sameAs 1531401474 @default.
- W1531401474 citedByCount "41" @default.
- W1531401474 countsByYear W15314014742012 @default.
- W1531401474 countsByYear W15314014742016 @default.
- W1531401474 crossrefType "journal-article" @default.
- W1531401474 hasAuthorship W1531401474A5013526431 @default.
- W1531401474 hasAuthorship W1531401474A5036828560 @default.
- W1531401474 hasAuthorship W1531401474A5077374522 @default.
- W1531401474 hasAuthorship W1531401474A5082654587 @default.
- W1531401474 hasAuthorship W1531401474A5085501629 @default.
- W1531401474 hasAuthorship W1531401474A5086448751 @default.
- W1531401474 hasAuthorship W1531401474A5087207909 @default.
- W1531401474 hasBestOaLocation W15314014741 @default.
- W1531401474 hasConcept C104317684 @default.
- W1531401474 hasConcept C109825262 @default.
- W1531401474 hasConcept C138885662 @default.
- W1531401474 hasConcept C150194340 @default.
- W1531401474 hasConcept C153911025 @default.
- W1531401474 hasConcept C159654299 @default.
- W1531401474 hasConcept C163764329 @default.
- W1531401474 hasConcept C203014093 @default.
- W1531401474 hasConcept C2778724333 @default.
- W1531401474 hasConcept C2780801004 @default.
- W1531401474 hasConcept C36394416 @default.
- W1531401474 hasConcept C41895202 @default.
- W1531401474 hasConcept C54009773 @default.
- W1531401474 hasConcept C542903549 @default.
- W1531401474 hasConcept C54355233 @default.
- W1531401474 hasConcept C86803240 @default.
- W1531401474 hasConceptScore W1531401474C104317684 @default.
- W1531401474 hasConceptScore W1531401474C109825262 @default.
- W1531401474 hasConceptScore W1531401474C138885662 @default.
- W1531401474 hasConceptScore W1531401474C150194340 @default.
- W1531401474 hasConceptScore W1531401474C153911025 @default.
- W1531401474 hasConceptScore W1531401474C159654299 @default.
- W1531401474 hasConceptScore W1531401474C163764329 @default.
- W1531401474 hasConceptScore W1531401474C203014093 @default.
- W1531401474 hasConceptScore W1531401474C2778724333 @default.
- W1531401474 hasConceptScore W1531401474C2780801004 @default.
- W1531401474 hasConceptScore W1531401474C36394416 @default.
- W1531401474 hasConceptScore W1531401474C41895202 @default.
- W1531401474 hasConceptScore W1531401474C54009773 @default.
- W1531401474 hasConceptScore W1531401474C542903549 @default.
- W1531401474 hasConceptScore W1531401474C54355233 @default.
- W1531401474 hasConceptScore W1531401474C86803240 @default.
- W1531401474 hasIssue "5" @default.
- W1531401474 hasLocation W15314014741 @default.
- W1531401474 hasLocation W15314014742 @default.
- W1531401474 hasOpenAccess W1531401474 @default.
- W1531401474 hasPrimaryLocation W15314014741 @default.
- W1531401474 hasRelatedWork W1522320206 @default.
- W1531401474 hasRelatedWork W1998326976 @default.
- W1531401474 hasRelatedWork W2102125851 @default.
- W1531401474 hasRelatedWork W2152089984 @default.
- W1531401474 hasRelatedWork W2242500747 @default.
- W1531401474 hasRelatedWork W2369282981 @default.
- W1531401474 hasRelatedWork W2387888620 @default.
- W1531401474 hasRelatedWork W2527224136 @default.
- W1531401474 hasRelatedWork W3216692889 @default.
- W1531401474 hasRelatedWork W4283218805 @default.
- W1531401474 hasVolume "151" @default.
- W1531401474 isParatext "false" @default.
- W1531401474 isRetracted "false" @default.
- W1531401474 magId "1531401474" @default.
- W1531401474 workType "article" @default.