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- W1531486768 abstract "The structural transition of an alternating purine-pyrimidine sequence (CG)5(TG)28) from the 5'-untranscribed region of the mouse ribosomal DNA was analyzed by two-dimensional gel electrophoresis and chemical probes. The repeat undergoes a supercoil-dependent gradual and oriented B-Z transition. At a threshold level of negative supercoiling, a limited region of the repeat encompassing the (CG)5 motif converts cooperatively into Z-DNA. As the superhelical stress increases, the Z-structure propagates along the remaining part of the repeat by successive transitions until the full-length sequence is converted. By in situ OsO4 probing experiments, we show also that this (TG)n-containing repeat adopts the Z-structure in Escherichia coli." @default.
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- W1531486768 date "1994-07-01" @default.
- W1531486768 modified "2023-09-30" @default.
- W1531486768 title "Gradual and oriented B-Z transition in 5'-untranscribed region of mouse ribosomal DNA." @default.
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- W1531486768 doi "https://doi.org/10.1016/s0021-9258(17)32158-0" @default.
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