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- W1531498081 abstract "Background: Myocardial infarction (MI) produces severe hypoxia within regions of the myocardium, resulting in the formation of scar tissue and significant cardiac cell death. Adult hearts contain endogenous cardiac stem cells (CSCs) that have regenerative capacity and participate in myocardial tissue homeostasis and repair post-MI, but are insufficient to promote complete regeneration. The histone deacetylase Sirtuin 1 (SIRT1) likely mediates this hypoxia-induced decrease in regeneration via roles in cell cycle progression and conferring protection from senescence and oxidative damage. Hypothesis: Hypoxia decreases CSC proliferation through reduced SIRT1-mediated deacetylation. Methods and Results: Murine CSCs were grown at room air (21% O2), physiologic (5% O2), and ischemic hypoxic (0.5% O2) conditions for 72 hours. Ischemic hypoxia, but not physiologic, reduced CSC proliferation and DNA synthesis to 25±2.0% (N=3; p<0.05) and 54±7.0% (N=7; p<0.05), respectively, relative to cells grown in room air. SIRT..." @default.
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- W1531498081 date "2014-11-25" @default.
- W1531498081 modified "2023-09-26" @default.
- W1531498081 title "Abstract 19165: Hypoxia-Induced Downregulation of Sirtuin 1 Impairs Cardiac Stem Cell Proliferation" @default.
- W1531498081 hasPublicationYear "2014" @default.
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