Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531504909> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1531504909 endingPage "2862" @default.
- W1531504909 startingPage "2856" @default.
- W1531504909 abstract "Free cells isolated from adult rat heart by the collagenase method were maintained in culture up to 21 h with or without an islet-activating protein (IAP) that had been purified from the culture medium of Bordetella pertussis. Short-term stimulation of beta-adrenergic or glucagon receptors in these cultured cells caused more accumulation of cAMP in cells precultured with IAP (IAP-treated) than in nontreated cells, although there was no significant difference in the baseline (non-stimulated) content of cAMP between these cells. Stimulation of muscarinic cholinergic or adenosine R-site receptors caused a marked inhibition of cAMP accumulation in nontreated cells in either the presence or absence of a beta-agonist (or glucagon); no such inhibition was essentially observed in IAP-treated cells. These actions of IAP developed gradually and were dose-dependent with the half-maximal concentration of approximately 80 ng/ml in culture. It is concluded that IAP may exert its unique influence on the heart cell membrane causing profound modification of the coupling mechanism involved in the receptor-mediated activation or inhibition of adenylate cyclase. This action of IAP differs clearly from that of cholera toxin which activates adenylate cyclase rather independently of the receptor functions in heart cells." @default.
- W1531504909 created "2016-06-24" @default.
- W1531504909 creator A5050650577 @default.
- W1531504909 creator A5060800501 @default.
- W1531504909 date "1981-03-01" @default.
- W1531504909 modified "2023-10-15" @default.
- W1531504909 title "Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells." @default.
- W1531504909 cites W1481499718 @default.
- W1531504909 cites W1488609485 @default.
- W1531504909 cites W1513161378 @default.
- W1531504909 cites W1775749144 @default.
- W1531504909 cites W1992742082 @default.
- W1531504909 cites W1996012192 @default.
- W1531504909 cites W2000591832 @default.
- W1531504909 cites W2007845552 @default.
- W1531504909 cites W2011539902 @default.
- W1531504909 cites W2019932147 @default.
- W1531504909 cites W2025609673 @default.
- W1531504909 cites W2028285911 @default.
- W1531504909 cites W2035962819 @default.
- W1531504909 cites W2054440253 @default.
- W1531504909 cites W2068447507 @default.
- W1531504909 cites W2072930282 @default.
- W1531504909 cites W2078020390 @default.
- W1531504909 cites W2094951225 @default.
- W1531504909 cites W2110246883 @default.
- W1531504909 cites W2158595527 @default.
- W1531504909 cites W2793654547 @default.
- W1531504909 doi "https://doi.org/10.1016/s0021-9258(19)69693-6" @default.
- W1531504909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6162842" @default.
- W1531504909 hasPublicationYear "1981" @default.
- W1531504909 type Work @default.
- W1531504909 sameAs 1531504909 @default.
- W1531504909 citedByCount "293" @default.
- W1531504909 countsByYear W15315049092012 @default.
- W1531504909 countsByYear W15315049092013 @default.
- W1531504909 countsByYear W15315049092021 @default.
- W1531504909 countsByYear W15315049092022 @default.
- W1531504909 crossrefType "journal-article" @default.
- W1531504909 hasAuthorship W1531504909A5050650577 @default.
- W1531504909 hasAuthorship W1531504909A5060800501 @default.
- W1531504909 hasBestOaLocation W15315049091 @default.
- W1531504909 hasConcept C126322002 @default.
- W1531504909 hasConcept C134018914 @default.
- W1531504909 hasConcept C165220095 @default.
- W1531504909 hasConcept C170493617 @default.
- W1531504909 hasConcept C185592680 @default.
- W1531504909 hasConcept C2779306644 @default.
- W1531504909 hasConcept C55493867 @default.
- W1531504909 hasConcept C71924100 @default.
- W1531504909 hasConcept C86803240 @default.
- W1531504909 hasConcept C95444343 @default.
- W1531504909 hasConceptScore W1531504909C126322002 @default.
- W1531504909 hasConceptScore W1531504909C134018914 @default.
- W1531504909 hasConceptScore W1531504909C165220095 @default.
- W1531504909 hasConceptScore W1531504909C170493617 @default.
- W1531504909 hasConceptScore W1531504909C185592680 @default.
- W1531504909 hasConceptScore W1531504909C2779306644 @default.
- W1531504909 hasConceptScore W1531504909C55493867 @default.
- W1531504909 hasConceptScore W1531504909C71924100 @default.
- W1531504909 hasConceptScore W1531504909C86803240 @default.
- W1531504909 hasConceptScore W1531504909C95444343 @default.
- W1531504909 hasIssue "6" @default.
- W1531504909 hasLocation W15315049091 @default.
- W1531504909 hasOpenAccess W1531504909 @default.
- W1531504909 hasPrimaryLocation W15315049091 @default.
- W1531504909 hasRelatedWork W1966504330 @default.
- W1531504909 hasRelatedWork W1966775726 @default.
- W1531504909 hasRelatedWork W1979139803 @default.
- W1531504909 hasRelatedWork W1991560548 @default.
- W1531504909 hasRelatedWork W2030889776 @default.
- W1531504909 hasRelatedWork W2037631372 @default.
- W1531504909 hasRelatedWork W2040058909 @default.
- W1531504909 hasRelatedWork W2063957970 @default.
- W1531504909 hasRelatedWork W2132898409 @default.
- W1531504909 hasRelatedWork W4249176446 @default.
- W1531504909 hasVolume "256" @default.
- W1531504909 isParatext "false" @default.
- W1531504909 isRetracted "false" @default.
- W1531504909 magId "1531504909" @default.
- W1531504909 workType "article" @default.