FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531532256> ?p ?o ?g. }

• W1531532256 endingPage "302" @default.
• W1531532256 startingPage "3297" @default.
• W1531532256 abstract "The accumulation of age pigment, or lipofuscin, in postmitotic cells appears to be a universal feature of the aging process in animals. In mammals, the lipofuscin content of the retinal pigment epithelium (RPE) increases progressively during senescence. Dietary restriction has been shown to slow the rate at which many biologic parameters change during aging. Experiments were conducted to determine if dietary restriction alters the rate of age pigment accumulation in the RPE.Male Wistar rats were placed on one of three dietary regimens starting at weaning. One group was fed a nutritionally complete diet ad libitum. Another group was fed the same diet but was only allowed to consume 60% as much food daily as the ad libitum group ate. The final group was fed ad libitum a nutritionally complete diet that had a lower caloric density per gram than the diets fed to the other animals primarily because of the replacement of carbohydrate with oat fiber. Ultrastructural morphometric analysis was used to determine the RPE age pigment content in the first group at 6 months of age, and in all of the groups at 18 months of age.Dietary restriction, achieved either by reducing total food intake or by reducing the caloric content of the diet, resulted in significant decreases in RPE lipofuscin accumulation.Dietary restriction provides a relatively simple means by which RPE age pigment content can be modulated. This should prove useful in assessing the role of RPE lipofuscin accumulation in age-related retinal disorders. That the oat fiber diet fed ad libitum was almost as effective as restriction of total food intake in slowing RPE age pigment accumulation indicates that the effect of restricted caloric intake is not mediated by almost constant hunger." @default.
• W1531532256 created "2016-06-24" @default.
• W1531532256 creator A5000958764 @default.
• W1531532256 creator A5002820528 @default.
• W1531532256 creator A5044264789 @default.
• W1531532256 creator A5053779749 @default.
• W1531532256 creator A5056435508 @default.
• W1531532256 creator A5074790517 @default.
• W1531532256 date "1993-11-01" @default.
• W1531532256 modified "2023-09-23" @default.
• W1531532256 title "Dietary restriction slows age pigment accumulation in the retinal pigment epithelium." @default.
• W1531532256 cites W108060262 @default.
• W1531532256 cites W1285309 @default.
• W1531532256 cites W1514163974 @default.
• W1531532256 cites W1521853181 @default.
• W1531532256 cites W1557519235 @default.
• W1531532256 cites W1562149213 @default.
• W1531532256 cites W1564909652 @default.
• W1531532256 cites W1972370280 @default.
• W1531532256 cites W1983379463 @default.
• W1531532256 cites W1989314580 @default.
• W1531532256 cites W1990200256 @default.
• W1531532256 cites W1998163413 @default.
• W1531532256 cites W2001142902 @default.
• W1531532256 cites W2003916088 @default.
• W1531532256 cites W2010933392 @default.
• W1531532256 cites W2013324569 @default.
• W1531532256 cites W2015082866 @default.
• W1531532256 cites W2033194748 @default.
• W1531532256 cites W2040586345 @default.
• W1531532256 cites W2067963550 @default.
• W1531532256 cites W2068093307 @default.
• W1531532256 cites W2086069880 @default.
• W1531532256 cites W2090505099 @default.
• W1531532256 cites W2109494581 @default.
• W1531532256 cites W2321527267 @default.
• W1531532256 cites W2732732038 @default.
• W1531532256 cites W437947800 @default.
• W1531532256 cites W589888840 @default.
• W1531532256 cites W87276380 @default.
• W1531532256 cites W2480642977 @default.
• W1531532256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8225864" @default.
• W1531532256 hasPublicationYear "1993" @default.
• W1531532256 type Work @default.
• W1531532256 sameAs 1531532256 @default.
• W1531532256 citedByCount "7" @default.
• W1531532256 countsByYear W15315322562013 @default.
• W1531532256 crossrefType "journal-article" @default.
• W1531532256 hasAuthorship W1531532256A5000958764 @default.
• W1531532256 hasAuthorship W1531532256A5002820528 @default.
• W1531532256 hasAuthorship W1531532256A5044264789 @default.
• W1531532256 hasAuthorship W1531532256A5053779749 @default.
• W1531532256 hasAuthorship W1531532256A5056435508 @default.
• W1531532256 hasAuthorship W1531532256A5074790517 @default.
• W1531532256 hasConcept C126322002 @default.
• W1531532256 hasConcept C134018914 @default.
• W1531532256 hasConcept C178790620 @default.
• W1531532256 hasConcept C185592680 @default.
• W1531532256 hasConcept C186198217 @default.
• W1531532256 hasConcept C2776099141 @default.
• W1531532256 hasConcept C2778024200 @default.
• W1531532256 hasConcept C2778411929 @default.
• W1531532256 hasConcept C2780655333 @default.
• W1531532256 hasConcept C2780827179 @default.
• W1531532256 hasConcept C28781525 @default.
• W1531532256 hasConcept C2992741425 @default.
• W1531532256 hasConcept C31903555 @default.
• W1531532256 hasConcept C40438245 @default.
• W1531532256 hasConcept C522857546 @default.
• W1531532256 hasConcept C55493867 @default.
• W1531532256 hasConcept C64584667 @default.
• W1531532256 hasConcept C71924100 @default.
• W1531532256 hasConcept C86803240 @default.
• W1531532256 hasConcept C95444343 @default.
• W1531532256 hasConceptScore W1531532256C126322002 @default.
• W1531532256 hasConceptScore W1531532256C134018914 @default.
• W1531532256 hasConceptScore W1531532256C178790620 @default.
• W1531532256 hasConceptScore W1531532256C185592680 @default.
• W1531532256 hasConceptScore W1531532256C186198217 @default.
• W1531532256 hasConceptScore W1531532256C2776099141 @default.
• W1531532256 hasConceptScore W1531532256C2778024200 @default.
• W1531532256 hasConceptScore W1531532256C2778411929 @default.
• W1531532256 hasConceptScore W1531532256C2780655333 @default.
• W1531532256 hasConceptScore W1531532256C2780827179 @default.
• W1531532256 hasConceptScore W1531532256C28781525 @default.
• W1531532256 hasConceptScore W1531532256C2992741425 @default.
• W1531532256 hasConceptScore W1531532256C31903555 @default.
• W1531532256 hasConceptScore W1531532256C40438245 @default.
• W1531532256 hasConceptScore W1531532256C522857546 @default.
• W1531532256 hasConceptScore W1531532256C55493867 @default.
• W1531532256 hasConceptScore W1531532256C64584667 @default.
• W1531532256 hasConceptScore W1531532256C71924100 @default.
• W1531532256 hasConceptScore W1531532256C86803240 @default.
• W1531532256 hasConceptScore W1531532256C95444343 @default.
• W1531532256 hasIssue "12" @default.
• W1531532256 hasLocation W15315322561 @default.
• W1531532256 hasOpenAccess W1531532256 @default.
• W1531532256 hasPrimaryLocation W15315322561 @default.

• next