Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531542811> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1531542811 abstract "The titin locus located on chromosome 2q24 in the human genome expresses about 100 kb full-length mRNAs, that are translated into giant up to 34.350-residue large polypeptides. Therefore, titin is by far the largest known protein. The titin protein is abundant in vertebrate muscles, where it spans half of the sarcomere. In situ, 1–2 μm long titin polypeptides establish a sarcomeric filament system that is critical for myofibrillar integrity and elasticity. Biomechanically, titin's intrinsic elasticity is fine-tuned in the different muscle tissues through alternative splicing, post-translational modifications and protein–protein interactions. Moreover, a plethora of molecular interactions with stress-regulated ligands positions titin centrally in stretch-dependent signalling in muscle. Therefore, mutations in this filament system are important causes of hereditary cardiomyopathies and muscular dystrophies.Key Concepts: Sarcomeres consist of precisely assembled proteins that together form the basic functional units of striated muscle and give rise to efficient and finely tuned contraction.In muscle tissues, 1–2 μm single titin polypeptide chains span half of the sarcomere.The intrasarcomeric filamentous titin protein provides sarcomeres with intrinsic elasticity and couples stretch-dependent signalling together with muscle remodelling.Titin molecule is tailored to physiological requirements of different muscles through alternative splicing, post-translational modifications and protein–protein interactions.Mutations in the titin gene are associated with different heart and skeletal muscle diseases.Keywords:muscle contraction;myofibrillar elasticity and signalling;sarcomere assembly" @default.
- W1531542811 created "2016-06-24" @default.
- W1531542811 creator A5003474405 @default.
- W1531542811 creator A5019267667 @default.
- W1531542811 creator A5044599389 @default.
- W1531542811 creator A5046297189 @default.
- W1531542811 date "2011-11-15" @default.
- W1531542811 modified "2023-09-24" @default.
- W1531542811 title "Titin Gene (TTN)" @default.
- W1531542811 cites W1977378217 @default.
- W1531542811 cites W2000971508 @default.
- W1531542811 cites W2026080348 @default.
- W1531542811 cites W2041663954 @default.
- W1531542811 cites W2046194099 @default.
- W1531542811 cites W2067901350 @default.
- W1531542811 cites W2071470129 @default.
- W1531542811 cites W2077487028 @default.
- W1531542811 cites W2091831926 @default.
- W1531542811 cites W2098587086 @default.
- W1531542811 cites W2102071784 @default.
- W1531542811 cites W2104627343 @default.
- W1531542811 cites W2107549503 @default.
- W1531542811 cites W2107575131 @default.
- W1531542811 cites W2122967682 @default.
- W1531542811 cites W2144214162 @default.
- W1531542811 cites W2150832969 @default.
- W1531542811 cites W2153177273 @default.
- W1531542811 doi "https://doi.org/10.1002/9780470015902.a0005021.pub2" @default.
- W1531542811 hasPublicationYear "2011" @default.
- W1531542811 type Work @default.
- W1531542811 sameAs 1531542811 @default.
- W1531542811 citedByCount "0" @default.
- W1531542811 crossrefType "reference-entry" @default.
- W1531542811 hasAuthorship W1531542811A5003474405 @default.
- W1531542811 hasAuthorship W1531542811A5019267667 @default.
- W1531542811 hasAuthorship W1531542811A5044599389 @default.
- W1531542811 hasAuthorship W1531542811A5046297189 @default.
- W1531542811 hasConcept C207200792 @default.
- W1531542811 hasConcept C68731436 @default.
- W1531542811 hasConcept C86803240 @default.
- W1531542811 hasConcept C90671521 @default.
- W1531542811 hasConcept C95444343 @default.
- W1531542811 hasConceptScore W1531542811C207200792 @default.
- W1531542811 hasConceptScore W1531542811C68731436 @default.
- W1531542811 hasConceptScore W1531542811C86803240 @default.
- W1531542811 hasConceptScore W1531542811C90671521 @default.
- W1531542811 hasConceptScore W1531542811C95444343 @default.
- W1531542811 hasLocation W15315428111 @default.
- W1531542811 hasOpenAccess W1531542811 @default.
- W1531542811 hasPrimaryLocation W15315428111 @default.
- W1531542811 hasRelatedWork W1591723242 @default.
- W1531542811 hasRelatedWork W2019468650 @default.
- W1531542811 hasRelatedWork W2069923609 @default.
- W1531542811 hasRelatedWork W2096728209 @default.
- W1531542811 hasRelatedWork W2122703252 @default.
- W1531542811 hasRelatedWork W2132994510 @default.
- W1531542811 hasRelatedWork W2141336992 @default.
- W1531542811 hasRelatedWork W2283053040 @default.
- W1531542811 hasRelatedWork W252451593 @default.
- W1531542811 hasRelatedWork W4360620193 @default.
- W1531542811 isParatext "false" @default.
- W1531542811 isRetracted "false" @default.
- W1531542811 magId "1531542811" @default.
- W1531542811 workType "reference-entry" @default.