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- W1531569394 abstract "Squalene synthase (SQS) catalyzes the first reaction of the branch of the isoprenoid metabolic pathway committed specifically to sterol biosynthesis. Regulation of SQS is thought to direct proximal intermediates in the pathway into either sterol or nonsterol branches in response to changing cellular requirements. The importance of SQS in cholesterol metabolism has stimulated research on the mechanism, structure, and regulation of the enzyme. SQS produces squalene, a C30 isoprenoid, in a two-step reaction in which two molecules of farnesyl diphosphate are condensed head to head. Site-directed mutagenesis of rat SQS has identified conserved Tyr, Phe, and Asp residues that are essential for function. The aromatic rings of Tyr and Phe are postulated to stabilize carbocation intermediates of the first and second half-reactions, respectively; the acidic Asp residues may be required for substrate binding. SQS activity, protein level, and gene transcription are strictly and coordinately regulated by cholesterol status, decreasing with cholesterol surfeit and increasing with cholesterol deficit. The human SQS (hSQS) gene has an unusually complex promoter with multiple binding sites for the sterol regulatory element binding proteins SREBP-1a and SREBP-2, and for accessory transcription factors known to be involved in the control of other sterol-responsive genes. SREBP-1a and SREBP-2 require different subsets of hSQS regulatory DNA elements to achieve maximal promoter activation. Current research is directed at elucidating the precise contribution made by individual SREBPs and accessory transcription factors to hSQS transcriptional control." @default.
- W1531569394 created "2016-06-24" @default.
- W1531569394 creator A5045376264 @default.
- W1531569394 creator A5051833701 @default.
- W1531569394 date "2000-01-01" @default.
- W1531569394 modified "2023-09-27" @default.
- W1531569394 title "Squalene synthase: Structure and regulation" @default.
- W1531569394 cites W105839754 @default.
- W1531569394 cites W1452088425 @default.
- W1531569394 cites W1489018692 @default.
- W1531569394 cites W1500418591 @default.
- W1531569394 cites W1501808185 @default.
- W1531569394 cites W1503880894 @default.
- W1531569394 cites W1511049324 @default.
- W1531569394 cites W1513222151 @default.
- W1531569394 cites W1520912904 @default.
- W1531569394 cites W1534973403 @default.
- W1531569394 cites W1538620024 @default.
- W1531569394 cites W1539499542 @default.
- W1531569394 cites W1544794592 @default.
- W1531569394 cites W1545863212 @default.
- W1531569394 cites W1547467983 @default.
- W1531569394 cites W1556597983 @default.
- W1531569394 cites W1562982017 @default.
- W1531569394 cites W1563467093 @default.
- W1531569394 cites W1566949129 @default.
- W1531569394 cites W1570291004 @default.
- W1531569394 cites W1572603460 @default.
- W1531569394 cites W1581140213 @default.
- W1531569394 cites W1591084420 @default.
- W1531569394 cites W1593557340 @default.
- W1531569394 cites W1596664454 @default.
- W1531569394 cites W1612399653 @default.
- W1531569394 cites W1633150347 @default.
- W1531569394 cites W1648032338 @default.
- W1531569394 cites W1661287973 @default.
- W1531569394 cites W1776144016 @default.
- W1531569394 cites W1829830007 @default.
- W1531569394 cites W1860242155 @default.
- W1531569394 cites W1871067114 @default.
- W1531569394 cites W1919752579 @default.
- W1531569394 cites W1964361564 @default.
- W1531569394 cites W1965565878 @default.
- W1531569394 cites W1965837065 @default.
- W1531569394 cites W1967502002 @default.
- W1531569394 cites W1969555177 @default.
- W1531569394 cites W1970065259 @default.
- W1531569394 cites W1972031892 @default.
- W1531569394 cites W1972894823 @default.
- W1531569394 cites W1974255105 @default.
- W1531569394 cites W1976551834 @default.
- W1531569394 cites W1977315314 @default.
- W1531569394 cites W197905089 @default.
- W1531569394 cites W1980455986 @default.
- W1531569394 cites W1982517502 @default.
- W1531569394 cites W1990121366 @default.
- W1531569394 cites W1992864925 @default.
- W1531569394 cites W1993928056 @default.
- W1531569394 cites W1994105720 @default.
- W1531569394 cites W1995881074 @default.
- W1531569394 cites W1999814505 @default.
- W1531569394 cites W1999916089 @default.
- W1531569394 cites W2001195445 @default.
- W1531569394 cites W2002249795 @default.
- W1531569394 cites W2002712119 @default.
- W1531569394 cites W2003187168 @default.
- W1531569394 cites W2005151453 @default.
- W1531569394 cites W2009624930 @default.
- W1531569394 cites W2010299622 @default.
- W1531569394 cites W2011187123 @default.
- W1531569394 cites W2016724302 @default.
- W1531569394 cites W2022026458 @default.
- W1531569394 cites W2023344829 @default.
- W1531569394 cites W2023632463 @default.
- W1531569394 cites W2033513498 @default.
- W1531569394 cites W2033692327 @default.
- W1531569394 cites W2034174805 @default.
- W1531569394 cites W2034207780 @default.
- W1531569394 cites W2035922719 @default.
- W1531569394 cites W2036350517 @default.
- W1531569394 cites W2038183822 @default.
- W1531569394 cites W2039999119 @default.
- W1531569394 cites W2040417680 @default.
- W1531569394 cites W2040560698 @default.
- W1531569394 cites W2042701219 @default.
- W1531569394 cites W2046903049 @default.
- W1531569394 cites W2047039177 @default.
- W1531569394 cites W2048272531 @default.
- W1531569394 cites W2048501252 @default.
- W1531569394 cites W2049761896 @default.
- W1531569394 cites W2052256523 @default.
- W1531569394 cites W2053916731 @default.
- W1531569394 cites W2055054372 @default.
- W1531569394 cites W2056400844 @default.
- W1531569394 cites W2058193911 @default.
- W1531569394 cites W2058614644 @default.
- W1531569394 cites W2060866593 @default.
- W1531569394 cites W2064969462 @default.