FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531600913> ?p ?o ?g. }

• W1531600913 endingPage "519" @default.
• W1531600913 startingPage "508" @default.
• W1531600913 abstract "Understanding the genetic basis of susceptibility to pathogens is an important goal of medicine and of evolutionary biology. A key first step toward understanding the genetics and evolution of any phenotypic trait is characterizing the role of mutation. However, the rate at which mutation introduces genetic variance for pathogen susceptibility in any organism is essentially unknown. Here, we quantify the per-generation input of genetic variance by mutation (VM) for susceptibility of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa (defined as the median time of death, LT50). VM for LT50 is slightly less than VM for a variety of life-history and morphological traits in this strain of C. elegans, but is well within the range of reported values in a variety of organisms. Mean LT50 did not change significantly over 250 generations of mutation accumulation. Comparison of VM to the standing genetic variance (VG) implies a strength of selection against new mutations of a few tenths of a percent. These results suggest that the substantial standing genetic variation for susceptibility of C. elegans to P. aeruginosa can be explained by polygenic mutation coupled with purifying selection." @default.
• W1531600913 created "2016-06-24" @default.
• W1531600913 creator A5021809480 @default.
• W1531600913 creator A5033550983 @default.
• W1531600913 creator A5039998915 @default.
• W1531600913 creator A5044560298 @default.
• W1531600913 creator A5052040431 @default.
• W1531600913 creator A5067592099 @default.
• W1531600913 creator A5069784379 @default.
• W1531600913 creator A5070271055 @default.
• W1531600913 creator A5078198741 @default.
• W1531600913 date "2015-01-19" @default.
• W1531600913 modified "2023-10-16" @default.
• W1531600913 title "The red death meets the abdominal bristle: Polygenic mutation for susceptibility to a bacterial pathogen in<i>Caenorhabditis elegans</i>" @default.
• W1531600913 cites W1662930619 @default.
• W1531600913 cites W1857512534 @default.
• W1531600913 cites W1915044809 @default.
• W1531600913 cites W1930635754 @default.
• W1531600913 cites W1955170827 @default.
• W1531600913 cites W1968991425 @default.
• W1531600913 cites W1981747359 @default.
• W1531600913 cites W1998224653 @default.
• W1531600913 cites W1999036695 @default.
• W1531600913 cites W2011812857 @default.
• W1531600913 cites W2012104592 @default.
• W1531600913 cites W2019415167 @default.
• W1531600913 cites W2021179500 @default.
• W1531600913 cites W2025930852 @default.
• W1531600913 cites W2028312442 @default.
• W1531600913 cites W2034431038 @default.
• W1531600913 cites W2034742459 @default.
• W1531600913 cites W2037383618 @default.
• W1531600913 cites W2037594820 @default.
• W1531600913 cites W2085034589 @default.
• W1531600913 cites W2088014737 @default.
• W1531600913 cites W2093774614 @default.
• W1531600913 cites W2101021939 @default.
• W1531600913 cites W2104587686 @default.
• W1531600913 cites W2104817697 @default.
• W1531600913 cites W2106307703 @default.
• W1531600913 cites W2107744564 @default.
• W1531600913 cites W2108874649 @default.
• W1531600913 cites W2117851139 @default.
• W1531600913 cites W2120749092 @default.
• W1531600913 cites W2122476222 @default.
• W1531600913 cites W2124187086 @default.
• W1531600913 cites W2130939625 @default.
• W1531600913 cites W2133499411 @default.
• W1531600913 cites W2139043858 @default.
• W1531600913 cites W2139079568 @default.
• W1531600913 cites W2150781510 @default.
• W1531600913 cites W2154913372 @default.
• W1531600913 cites W2155411515 @default.
• W1531600913 cites W2156643192 @default.
• W1531600913 cites W2158084232 @default.
• W1531600913 cites W2158339570 @default.
• W1531600913 cites W2159891210 @default.
• W1531600913 cites W2162555644 @default.
• W1531600913 cites W4240978954 @default.
• W1531600913 cites W4290346541 @default.
• W1531600913 doi "https://doi.org/10.1111/evo.12585" @default.
• W1531600913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4310795" @default.
• W1531600913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25495240" @default.
• W1531600913 hasPublicationYear "2015" @default.
• W1531600913 type Work @default.
• W1531600913 sameAs 1531600913 @default.
• W1531600913 citedByCount "6" @default.
• W1531600913 countsByYear W15316009132016 @default.
• W1531600913 countsByYear W15316009132017 @default.
• W1531600913 countsByYear W15316009132021 @default.
• W1531600913 crossrefType "journal-article" @default.
• W1531600913 hasAuthorship W1531600913A5021809480 @default.
• W1531600913 hasAuthorship W1531600913A5033550983 @default.
• W1531600913 hasAuthorship W1531600913A5039998915 @default.
• W1531600913 hasAuthorship W1531600913A5044560298 @default.
• W1531600913 hasAuthorship W1531600913A5052040431 @default.
• W1531600913 hasAuthorship W1531600913A5067592099 @default.
• W1531600913 hasAuthorship W1531600913A5069784379 @default.
• W1531600913 hasAuthorship W1531600913A5070271055 @default.
• W1531600913 hasAuthorship W1531600913A5078198741 @default.
• W1531600913 hasBestOaLocation W15316009132 @default.
• W1531600913 hasConcept C104317684 @default.
• W1531600913 hasConcept C105702510 @default.
• W1531600913 hasConcept C119599485 @default.
• W1531600913 hasConcept C127413603 @default.
• W1531600913 hasConcept C127716648 @default.
• W1531600913 hasConcept C154945302 @default.
• W1531600913 hasConcept C16108499 @default.
• W1531600913 hasConcept C19843653 @default.
• W1531600913 hasConcept C2776460866 @default.
• W1531600913 hasConcept C2776496032 @default.
• W1531600913 hasConcept C2778022156 @default.
• W1531600913 hasConcept C2778944004 @default.
• W1531600913 hasConcept C41008148 @default.
• W1531600913 hasConcept C501734568 @default.
• W1531600913 hasConcept C54355233 @default.
• W1531600913 hasConcept C58115284 @default.
• W1531600913 hasConcept C68873052 @default.

• next