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• W1531653947 abstract "Abstract The effect of testosterone enanthate administration was studied in male patients with cirrhosis of the liver by the measurement of testosterone (T), androstenedione (A), estrone (E1), and estradiol (E2) as well as of free T and free E2 in the plasma. The patients with cirrhosis of the liver were divided into three groups (I–III) according to clinical symptoms. Under basal conditions, T was decreased in the plasma, whereas A, E1, and E2 were mainly increased in the patients of groups II and III (patients with gynecomastia and those with gynecomastia and ascites). Only minimal hormonal changes were observed in patients without gynecomastia (group I). After the administration of 250-mg T-enanthate, i.m. T increased by a factor of 13.9 in the patients of group III compared to a factor of 2.4 in the controls and remained elevated for a longer period in the patients. The maximum concentration of the estrogens was 62 ± 6 pg E1/ml and 42 ± 4 pg E2/ml (x ± SEM) in the controls and 272 ± 22 and 110 ± 11 pg/ml in group III, respectively. The increased conversion of T was not limited to the estrogens, because A was found to be elevated by a factor of 2–3 (group III) as compared to the controls (0.63 ± 0.09 ng/ml). Although the maximal values of T were found to be more increased in the patients (22.8 ± 1.6 ng/ml in group III) than in the controls (13.2 ± 1.0 ng/ml), the concentration of free T was only moderately increased in the patients (group III: 392 ± 25 pg/ml; controls: 563 ± 29 pg/ml) because of enhanced binding to sexual hormone-binding globulin. It was of special interest that the balance between sexual hormones, which in cirrhosis of the liver is greatly enhanced in favor of the estrogens, was nearly normalized after T-administration. The same was true for the concentration of free T and free E2. It is concluded that the increased conversion of androgens to estrogens leads to higher estrogen plasma values after exogenous T-administration. Nevertheless, because of the greatly elevated T-values, the imbalance between heterosexual hormones, which sometimes has been considered to be responsible for signs of increased estrogenic activity in the patients, is nearly normalized. The study of T-administration provides a valuable approach for investigating steroid abnormalities in liver damages." @default.
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• W1531653947 date "1979-02-01" @default.
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• W1531653947 title "Effect of testosterone application on hormone concentrations of androgens and estrogens in male patients with cirrhosis of the liver" @default.
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• W1531653947 doi "https://doi.org/10.1016/0016-5085(79)90327-5" @default.
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