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- W1531695810 abstract "Abstract Hematopoietic stem cell transplantation is characterized by a prolonged period of humoral immunodeficiency. We have previously shown that the deficiencies are probably not due to the failure to utilize the appropriate V regions in the pre-immune repertoire. However, a striking observation, which correlated with the absence of immunoglobulin IgD− cells and was consistent with a defect in antigen-driven responses, was that rearrangements in bone marrow transplant (BMT) recipients exhibited much less somatic mutation than did rearrangements obtained from healthy subjects. In this paper, we present evidence suggesting that naive B cells obtained from BMT recipients lack the capacity to accumulate somatic mutations in a T-cell–dependent manner compared with healthy subjects. This appears to be a B-cell–autonomous deficit because T cells from some patients, which were not able to support the accumulation of mutations in autologous naive B cells, were able to support accumulation of mutations in heterologous healthy-subject naive B cells." @default.
- W1531695810 created "2016-06-24" @default.
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- W1531695810 date "2000-08-01" @default.
- W1531695810 modified "2023-10-03" @default.
- W1531695810 title "B-cell–autonomous somatic mutation deficit following bone marrow transplant" @default.
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- W1531695810 doi "https://doi.org/10.1182/blood.v96.3.1064" @default.
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