Matches in SemOpenAlex for { <https://semopenalex.org/work/W1531720912> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1531720912 endingPage "2365" @default.
- W1531720912 startingPage "2358" @default.
- W1531720912 abstract "Abstract The inhibitor response properties of the mitochondrial DPNH dehydrogenase have been studied with both the particle-bound and the soluble forms of the enzyme. Electron transfer from the particle-bound DPNH dehydrogenase to the respiratory chain is inhibited by barbiturates, Demerol, rotenone, and piericidin A, whereas the activities of the soluble enzyme are essentially unaffected by these inhibitors. In contrast, the ferricyanide reductase, as well as other diaphorase activities, of the soluble DPNH dehydrogenase is inhibited by mercurials, whereas the bound dehydrogenase appears to be protected against such mercurial attack. o-Phenanthroline interacts with the soluble dehydrogenase, inhibits its activities, and causes the release of labile sulfide from the enzyme. However, other bidentate iron chelators such as bathophenanthroline sulfonate and Tiron do not inhibit the enzyme but interact with it and protect it against inhibition by o-phenanthroline. These studies have indicated that in DPNH dehydrogenase the complex among iron, labile sulfide groups, and cysteine sulfur residues must have a tetrahedral structure. Adenosine phosphates inhibit DPNH dehydrogenase in the same manner as does DPN, but adenosine, nicotinamide mononucleotide, and NMNH are not inhibitory. Guanidinium compounds activate the soluble DPNH dehydrogenase, but inhibit the coenzyme Q reductase activity of the particulate DPNH-coenzyme Q reductase (Complex I). The activating effect of guanidinium compounds on the soluble dehydrogenase is associated not only with an increase in the value of Vmax, but also with a substantial decrease in the value of Kmdpnh (3-fold at 50 mm guanidine)." @default.
- W1531720912 created "2016-06-24" @default.
- W1531720912 creator A5007925808 @default.
- W1531720912 creator A5025581762 @default.
- W1531720912 creator A5088361501 @default.
- W1531720912 date "1969-05-01" @default.
- W1531720912 modified "2023-09-30" @default.
- W1531720912 title "Inhibitors and Activators of the Mitochondrial Reduced Diphosphopyridine Nucleotide Dehydrogenase" @default.
- W1531720912 cites W10205671 @default.
- W1531720912 cites W1485465502 @default.
- W1531720912 cites W1507356284 @default.
- W1531720912 cites W1535540896 @default.
- W1531720912 cites W1541571587 @default.
- W1531720912 cites W1610597612 @default.
- W1531720912 cites W1618428643 @default.
- W1531720912 cites W162787695 @default.
- W1531720912 cites W1977118578 @default.
- W1531720912 cites W1991033215 @default.
- W1531720912 cites W2004718659 @default.
- W1531720912 cites W2029150765 @default.
- W1531720912 cites W2039280872 @default.
- W1531720912 cites W2046322417 @default.
- W1531720912 cites W2066377136 @default.
- W1531720912 cites W2279913030 @default.
- W1531720912 cites W52539439 @default.
- W1531720912 cites W1907199996 @default.
- W1531720912 doi "https://doi.org/10.1016/s0021-9258(19)78233-7" @default.
- W1531720912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4306510" @default.
- W1531720912 hasPublicationYear "1969" @default.
- W1531720912 type Work @default.
- W1531720912 sameAs 1531720912 @default.
- W1531720912 citedByCount "59" @default.
- W1531720912 countsByYear W15317209122013 @default.
- W1531720912 countsByYear W15317209122014 @default.
- W1531720912 countsByYear W15317209122016 @default.
- W1531720912 countsByYear W15317209122022 @default.
- W1531720912 crossrefType "journal-article" @default.
- W1531720912 hasAuthorship W1531720912A5007925808 @default.
- W1531720912 hasAuthorship W1531720912A5025581762 @default.
- W1531720912 hasAuthorship W1531720912A5088361501 @default.
- W1531720912 hasBestOaLocation W15317209121 @default.
- W1531720912 hasConcept C104317684 @default.
- W1531720912 hasConcept C185592680 @default.
- W1531720912 hasConcept C24586158 @default.
- W1531720912 hasConcept C2776319529 @default.
- W1531720912 hasConcept C512185932 @default.
- W1531720912 hasConcept C55493867 @default.
- W1531720912 hasConceptScore W1531720912C104317684 @default.
- W1531720912 hasConceptScore W1531720912C185592680 @default.
- W1531720912 hasConceptScore W1531720912C24586158 @default.
- W1531720912 hasConceptScore W1531720912C2776319529 @default.
- W1531720912 hasConceptScore W1531720912C512185932 @default.
- W1531720912 hasConceptScore W1531720912C55493867 @default.
- W1531720912 hasIssue "9" @default.
- W1531720912 hasLocation W15317209121 @default.
- W1531720912 hasOpenAccess W1531720912 @default.
- W1531720912 hasPrimaryLocation W15317209121 @default.
- W1531720912 hasRelatedWork W1512030089 @default.
- W1531720912 hasRelatedWork W1957181770 @default.
- W1531720912 hasRelatedWork W1969499600 @default.
- W1531720912 hasRelatedWork W2018943552 @default.
- W1531720912 hasRelatedWork W2054430652 @default.
- W1531720912 hasRelatedWork W2064137515 @default.
- W1531720912 hasRelatedWork W2468561767 @default.
- W1531720912 hasRelatedWork W2485047448 @default.
- W1531720912 hasRelatedWork W4251012387 @default.
- W1531720912 hasRelatedWork W4256548481 @default.
- W1531720912 hasVolume "244" @default.
- W1531720912 isParatext "false" @default.
- W1531720912 isRetracted "false" @default.
- W1531720912 magId "1531720912" @default.
- W1531720912 workType "article" @default.