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• W1531827852 abstract "Summary. The leaf, seed and almonds of Melia azedarach grown in Algeria were defatted and extracted with three solvents, aqueous (70%, v/v) acetone, (80%) ethanol and water and evaluated for antioxidant activity in relation to phenolic contents. Defatting improved the total phenolic and tannin contents and antioxidant activities of extracts. Aqueous ethanol (50%) extracted the highest level of total phenolics from the leaf at about 98 mg/g catechin equivalent exhibiting the strongest antioxidant (139 mg/g Trolox equivalent). The defatted aqueous ethanol (50%) leaf extract induced the least lipid peroxidation, an indicator for mitigating oxidative stress. Melia azedarach water and aqueous ethanol (50%) leaf extracts contained considerable amounts of quercetin derivatives and rutin (7-13 and 5-10 mg/g of dry weight, respectively) and exerted strong anti-inflammatory effects by inhibiting human monoacylglycerol lipase (MAGL). Industrial relevance. Immunity ingredients, in addition to their potent antioxidant activity, are of significant interest in nutraceuticals particularly of naturally derived compounds that reduce the risk of disease and conditions. The present study demonstrates that Melia azedarach water and aqueous ethanol (50%) leaf extracts exhibit strong antioxidant and anti-inflammatory activity by inhibiting human monoacylglycerol lipase (MAGL). Human MAGL inhibitors are rarely found naturally and its presence in natural products, particularly in Melia azedarach extracts provides a venue for its use mitigating CNS diseases where the imbalance of endocannabinoids plays a major role. Keywords. Melia azedarach ; antioxidant activity; anti-inflammatory; lipid peroxidation; lipase inhibition" @default.
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• W1531827852 date "2013-03-13" @default.
• W1531827852 modified "2023-10-01" @default.
• W1531827852 title "Phenolics, antioxidant and anti-inflammatory activities of Melia azedarach extracts" @default.
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