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- W1531941372 abstract "Publisher Summary This chapter discusses the cell biological mechanisms through which prokaryotes develop multidrug resistance. The majority of bacterial multidrug transporters characterized thus far, operates via a secondary transport mechanism. A number of genes encoding TEXANs and Mini TEXANs are cloned and sequenced. Analysis of these primary sequences reveals a striking similarity in the overall structure, suggesting that the proteins may function via a similar mechanism. Transport studies in membrane vesicles of Lactococcus lactis ( L. lactis )and Escherichia coli ( E. coli )are demonstrated the drug/proton antiport mechanism of the TEXAN LmrP. Smr and EmrE are purified and characterized upon reconstitution into proteoliposomes. These studies exhibit that a single multidrug resistance protein is able to function as a drug pump, and show the Δp-dependence of drug transport via the Mini TEXANs. The discovery of the ABC-type multidrug transporter LmrA in L. lactis shows overlap with that of the human multidrug resistance P-glycoprotein, the TEXANs LmrP and Bmr, and Mini TEXANs Smr, EmrE and QacC. On the other hand, the substrate specificity of these multidrug transporters is very different from that of the TetA(B) and other transporters dedicated to the efflux of a specific drug or class of drugs." @default.
- W1531941372 created "2016-06-24" @default.
- W1531941372 creator A5038964630 @default.
- W1531941372 creator A5079764701 @default.
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- W1531941372 date "1996-01-01" @default.
- W1531941372 modified "2023-09-27" @default.
- W1531941372 title "Chapter 8 Multidrug resistance in prokaryotes: Molecular mechanisms of drug efflux" @default.
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