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• W1531991569 abstract "Background: Aberrant Wingless type 1 glycoprotein (Wnt) pathway in ameloblastomas and a role of syndecan‐1 (SDC1) in activating Wnt signalling were perspected. SDC1 shifting from epithelium to stroma was reported in invasive non‐odontogenic neoplasms. The aim of this study was to reveal the role of SDC1 and Wnt1 in intraosseous ameloblastomas (IA s ). Methods: SDC1 and Wnt1 expressions were investigated in 29 ameloblastoma subtypes and seven tooth buds. Results: SDC1 immunostaining strongly depicted stromal cells, extracellular matrix (ECM) and basement membranes of ameloblastomas. It also showed epithelial tumour cells in the acanthomatous and plexiform subtypes, and it often occurred in stellate reticulum cells and basal ameloblasts of tooth buds. Parallel Wnt1 expression occurred in ameloblastomatous epithelial cells, but it was common in basal cells of tooth buds too. Statistically, a significant correlation was found between the percentage of IA s ‐bearing SDC1‐positive stromal cells and ECM and the percentage of IA s ‐bearing Wnt1‐positive epithelial cells. Conclusions: A role of SDC1 in stromal cells and ECM can be hypothesized as a critical factor for carcinogenesis and local invasiveness of IA s ." @default.
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• W1531991569 date "2007-04-20" @default.
• W1531991569 modified "2023-10-16" @default.
• W1531991569 title "Syndecan-1 and Wingless-type protein-1 in human ameloblastomas" @default.
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• W1531991569 doi "https://doi.org/10.1111/j.1600-0714.2007.00537.x" @default.
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