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• W1531998857 abstract "The interphotoreceptor retinoid-binding protein (IRBP) gene possesses an unusual structure, encoding multiple Repeats, each consisting of about 300 amino acids. Our goals were to gain insight into the function of IRBP, and to test the current model for the evolution of IRBP, in which Repeats were replicated from a simpler ancestral gene.We employed a bioinformatics approach to analyze IRBP loci in recently completed or near-complete genome sequences of several vertebrates and nonvertebrate chordates. IRBP gene expression in zebrafish was evaluated by reverse transcriptase PCR (RT-PCR) and in situ mRNA hybridizations with gene-specific probes.Patterns of exons and introns in the IRBP genes of tetrapods were highly similar, as were predicted amino acid sequences and Repeat structures. IRBP gene structure in teleost fish was more variable, and we report a new gene structure for two species, the Japanese puffer fish (Takifugu rubripes) and the zebrafish (Danio rerio). These teleost genomes contain a two-gene IRBP locus arranged head-to-tail in which the first gene, Gene 1, is intronless and contains a single large exon encoding three complete Repeats. It is followed by a second gene, Gene 2, which corresponds to the previously reported gene consisting of two Repeats spread across four exons and three introns. Each of the two zebrafish genes is transcribed. Gene 2 is expressed in the photoreceptors and RPE, and Gene 1 is expressed in the inner nuclear layer and weakly in the ganglion cell layer.The tetrapod IRBP gene structure is highly conserved while the teleost fish gene structure was a surprise: It appears to be a two-gene locus with distinct Repeat organization in each open reading frame. This gene structure and gene expression data are consistent with possible neofunctionalization or sub-function partitioning of Gene 1 and Gene 2 in the zebrafish. We suggest that the two-gene locus in teleost fish arose as a consequence of either the known whole genome duplication or single gene tandem duplication." @default.
• W1531998857 created "2016-06-24" @default.
• W1531998857 creator A5018003050 @default.
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• W1531998857 date "2006-12-09" @default.
• W1531998857 modified "2023-09-24" @default.
• W1531998857 title "Interphotoreceptor retinoid-binding protein gene structure in tetrapods and teleost fish." @default.
• W1531998857 cites W129174540 @default.
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• W1531998857 cites W1523381267 @default.
• W1531998857 cites W1527872783 @default.
• W1531998857 cites W1533138158 @default.
• W1531998857 cites W1542532287 @default.
• W1531998857 cites W1575252597 @default.
• W1531998857 cites W1589587808 @default.
• W1531998857 cites W1597109281 @default.
• W1531998857 cites W1602141111 @default.
• W1531998857 cites W1897014303 @default.
• W1531998857 cites W1952433052 @default.
• W1531998857 cites W1966006200 @default.
• W1531998857 cites W1969394126 @default.
• W1531998857 cites W1971063924 @default.
• W1531998857 cites W1973042776 @default.
• W1531998857 cites W1975075223 @default.
• W1531998857 cites W1978468062 @default.
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• W1531998857 cites W1992598133 @default.
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• W1531998857 cites W2018392902 @default.
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• W1531998857 cites W2054508286 @default.
• W1531998857 cites W2055043387 @default.
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• W1531998857 cites W2068789381 @default.
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• W1531998857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2898515" @default.
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