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- W1532065599 abstract "Climacteric symptoms in the menopausal woman are perplexing to the physician. Recent literature concerning the relationship of estrogen to carcinogenesis has caused many women to discontinue this medication; thus, there is a need for an alternative therapy for the relief of these symptoms. The drug medroxyprogesterone acetate (Depo-Provera) was assessed in a double-blind, randomized, placebo-controlled study involving 48 subjects. Only one of the placebo-treated patients claimod any relief from climacteric symptoms while only two of the patients who received the study drug noted little or no relief (P < 0.0001). Relief from climacteric symptoms began at 4 to 7 days after entry into the study and extended for 8 to 20 weeks. The only side effects were withdrawal bleeding and a slight, transient weight gain. Depo-Provera appears to be a reliable substitute for estrogen in the treatment of climacteric symptoms. Further investigations with this medication seem indicated." @default.
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- W1532065599 date "1980-09-01" @default.
- W1532065599 modified "2023-10-17" @default.
- W1532065599 title "The use of medroxyprogesterone acetate for relief of climacteric symtoms" @default.
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- W1532065599 doi "https://doi.org/10.1016/0002-9378(80)90017-4" @default.
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